慢性膝骨关节炎患者大脑结构形态的改变  

Brain structure and morphology changes in patients with chronic knee osteoarthritis

作　　者：叶晋 吴一玉 张弛 刘金勇 蔡树河 连晓文 YE Jin;WU Yiyu;ZHANG Chi(Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou,350003)

机构地区：[1]福建中医药大学附属康复医院,福建省福州市350003 [2]福建省康复技术重点实验室 [3]福建中医药大学康复医学院

出　　处：《中国康复医学杂志》2025年第3期369-374,共6页Chinese Journal of Rehabilitation Medicine

基　　金：国家自然科学基金项目(82104969);福建省康复技术重点实验室项目(KF2019013)。

摘　　要：目的:探索慢性膝骨关节炎患者大脑结构形态的变化特点。方法:使用基于体素的形态学测量分析(voxel-based morphometry,VBM)和基于表面的形态学测量分析(surfacebased morphometry,SBM)以及基于灰质体积构建的结构协变网络(structural covariance networks,SCN)分析慢性膝骨关节炎(knee osteoarthritis,KOA)患者大脑结构形态与健康受试者(healthy control,HC)间的差异。结果:(1)VBM分析:与HC受试者相比较,慢性KOA患者以左侧颞极(temporal pole)为中心区域的灰质体积显著减小(voxels水平,P<0.001;cluster水平,P=0.049,FWE校正,voxels size=833)。(2)SBM分析:与HC受试者相比较,慢性KOA患者左侧额下回盖部(pars opercularis)区域脑沟深度显著减小(voxels水平,P<0.001;cluster水平,P=0.003,FWE校正,voxels size=293)。(3)SCN分析:与HC受试者相比较,慢性KOA患者基于局部灰质体积构建的SCN鲁棒性强于HC受试者(P=0.032)。结论:慢性KOA患者存在大脑结构形态的异常,这为慢性KOA对中枢神经系统可能的影响提供了新的理解。Objective:To explore the characteristics of brain structure and morphology changes in patients with chronic knee osteoarthritis(OA).Method:Voxel-based morphometry(VBM)analysis,surface-based morphometry(SBM)analysis and structural covariance networks(SCN)based on gray matter volume were used to exam the differences in brain structure and morphology between patients with chronic knee osteoarthritis(KOA)and healthy control(HC).Result:(1)VBM analysis:Compared with HC subjects,chronic KOA patients showed a significant reduction in gray matter volume of the left temporal pole as the central region(voxels level,P<0.001;cluster level,P=0.049,FWE correction,voxels size=833).(2)SBM analysis:Compared with HC subjects,the sulcus depth in the pars opercularis of the left inferior frontal gyrus decreased significantly in patients with chronic KOA(voxels level,P<0.001;cluster level,P=0.003,FWE correction,voxels size=293).(3)SCN analysis:Compared with HC subjects,the SCN constructed based on local gray matter volume in patients with chronic KOA was more robust than that in healthy controls(P=0.032).Conclusion:Chronic KOA patients have structural abnormalities in the brain,providing a new insights into the potential impact of chronic KOA on the central nervous system.

关 键 词：膝骨关节炎 磁共振成像 灰质体积 脑沟深度 结构协变网络 

分 类 号：R684[医药卫生—骨科学]