基于痰瘀互结理论探讨内皮损伤与动脉粥样硬化关系  

Exploration on the Relationship between Endothelial Injury and Atherosclerosis Based on the Theory of Phlegm and Stasis Interconnection

作　　者：王东东 吕东岭[1] WANG Dongdong;LYU Dongling(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《中国中医药图书情报杂志》2025年第2期21-24,共4页Chinese Journal of Library and Information Science for Traditional Chinese Medicine

基　　金：江苏省中医药科技发展计划重点项目(ZT202203)。

摘　　要：血管内皮损伤是导致动脉粥样硬化发生、发展的主要因素之一。泡沫细胞聚集、凋亡、调控基因蛋白表达均会影响血管内皮细胞功能。“痰瘀互结”理论是从中医角度解释动脉粥样硬化的发生、发展、预后。“痰瘀互结”理论与血管内皮损伤关系密切,本文通过中西医不同角度探讨内皮损伤与动脉粥样硬化的关系,以中医化痰祛瘀之法改善血管内皮损伤,治疗动脉粥样硬化进行总结,为中医药治疗动脉粥样硬化提供思路。Endothelial injury is one of the main factors leading to the occurrence and development of atherosclerosis(AS).Foam cell aggregation,apoptosis,regulation of gene protein expression will affect the function of vascular endothelial cells.The theory of phlegm and stasis interconnection is to explain the occurrence,development and prognosis of AS from the perspective of TCM.The theory of phlegm and stasis interconnection is closely related to endothelial injury in blood vessels.This article discussed the relationship between endothelial injury and AS from different perspectives of traditional Chinese and Western medicine,and summarized the method of resolving phlegm and removing blood stasis in TCM to improve vascular endothelial injury and treat AS as the target to provide ideas for TCM to treat AS.

关 键 词：内皮损伤 痰瘀互结证 动脉粥样硬化 

分 类 号：R255.6[医药卫生—中医内科学]