当归多糖抗脑缺血再灌注损伤作用机制研究进展  

Research Progress in the Mechanism of Angelicae Sinensis Radix Polysaccharides against Cerebral Ischemia Reperfusion Injury

作　　者：董建华[1] 惠渊 周学锐 王欢 李妍怡[2] 巩婷[2] DONG Jianhua;HUI Yuan;ZHOU Xuerui;WANG Huan;LI Yanyi;GONG Ting(Gansu University of Chinese Medicine,Lanzhou 730030,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730030 [2]甘肃省中医院,甘肃兰州730050

出　　处：《中国中医药图书情报杂志》2025年第2期234-238,共5页Chinese Journal of Library and Information Science for Traditional Chinese Medicine

基　　金：甘肃省联合科研基金(23JRRA1531)。

摘　　要：脑缺血再灌注损伤病理过程复杂,其预防和治疗对于缺血性脑血管病恢复相当重要。中医学治疗脑缺血疾病广泛应用当归,当归多糖为当归主要有效成分,具有改善贫血、抗炎、抗氧化、保护脏器缺血损伤、免疫调节、抗肿瘤等多重药理作用。当归多糖能通过调控多种信号通路,抑制和促进相关生物分子的表达来发挥抗脑缺血再灌注损伤作用。本文对当归多糖抗脑缺血再灌注损伤作用机制进行综述,为当归多糖抗脑缺血再灌注损伤作用机制的进一步研究及临床转化提供参考。The pathological process of cerebral ischemia reperfusion injury is very complex and involves many mechanisms.Its prevention and treatment are very important in the recovery of ischemic cerebrovascular disease.Angelicae Sinensis Radix has been widely used in TCM for the treatment of cerebral ischemia.Angelicae Sinensis Radix polysaccharide is one of the main effective components of Angelicae Sinensis Radix,which has multiple pharmacological effects such as improving anemia,anti-inflammation,anti-oxidation,protecting organ ischemic injury,immune regulation and anti-tumor.Angelicae Sinensis Radix polysaccharide can inhibit and promote the expression of related biomolecules by regulating various signaling pathways to play an anti-cerebral ischemia reperfusion injury role.This article reviewed the mechanism of Angelicae Sinensis Radix polysaccharide against cerebral ischemia reperfusion injury,and provided references for further research and clinical transformation of the mechanism of Angelicae Sinensis Radix polysaccharide against cerebral ischemia reperfusion injury.

关 键 词：当归多糖 脑缺血再灌注 作用机制 综述 

分 类 号：R255.2[医药卫生—中医内科学]