男性久坐行为与精子质量及辅助生殖结局的相关性研究  

Correlation between Male Sedentary Behaviors and Sperm Quality,Assisted Reproductive Outcomes

作　　者：陈小燕[1] 张娟[1] 赵纯[1] 季娟[1] 赵静[1] CHEN Xiao-yan;ZHANG Juan;ZHAO Chun;JI Juan;ZHAO Jing(Department of Reproductive Medicine,Women′s Hospital of Nanjing Medical University,Nanjing Women and Children′s Healthcare Hospital,Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)生殖医学中心,210004

出　　处：《国际生殖健康/计划生育杂志》2025年第2期95-99,共5页Journal of International Reproductive Health/Family Planning

摘　　要：目的:探讨男性久坐对精子质量、辅助生殖结局的影响。方法:采用前瞻性队列研究,选取2021年1月—2022年10月南京医科大学附属妇产医院生殖医学中心收治的第1次行辅助生殖助孕的患者为研究对象,根据国际体力活动问卷评分结果分为久坐组和非久坐组,再采用倾向性评分匹配法(propensity score matching,PSM)将久坐组与非久坐组以1∶1的比例进行匹配,追踪随访6个月,对比2组患者的一般资料、精子质量及辅助生殖结局。结果:共纳入2002例患者为研究对象,其中久坐组1052例,非久坐组950例。匹配后2组各有857例患者,2组患者的所有一般资料指标比较,差异均无统计学意义(均P>0.05),匹配成功。久坐组的精子浓度较非久坐组患者低,且受精率低于非久坐组(均P<0.05);2组间其他指标相比差异均无统计学意义(均P>0.05)。结论:长期久坐行为对男性的精子质量、辅助生殖结局有一定的影响,提示临床工作者应关注助孕患者的久坐问题,做好健康宣教纠正患者不良生活习惯,并协助其制定家庭锻炼计划,从而提升助孕成功率。Obejective:To investigate the correlation between male sedentary behaviors and sperm quality,assisted reproductive outcomes.Methods:In this prospective cohort study,the recruited patients who underwent assisted reproduction for the first time from January 2021 to October 2022 were divided them into the sedentary group and the non-sedentary group,according to the International Physical Activity Questionnaire(IPAQ)score.And the two groups was matched at ratio of 1:1 used the propensity score matching(PSM)method.General information,sperm quality,and assisted reproductive outcomes were compared between the two groups for six months follow-up.Results:A total of 2002 participants were included in the study,including 1052 in the sedentary group and 950 in the nonsedentary group.After the propensity score matching method,there were 857 participants left in each group and their baseline information were equal between the two groups(all P>0.05).The sedentary group had poorer sperm density and lower fertilization rate than the non-sedentary group(both P<0.05).There were no statistically significant differences in other indicators between the two groups(all P>0.05).Conclusions:Long-term sedentary behavior has a certain impact on male sperm quality and assisted reproductive outcomes,suggesting that clinical workers should pay attention to the sedentary problem of patients and do a good job of education or intervention to improve the patients′health behaviors.

关 键 词：不育 女性 不育 男性 久坐生活方式 生殖技术 辅助 结局 

分 类 号：R714.8[医药卫生—妇产科学]