卵母细胞衰老机制的研究进展  

Research Progress on the Mechanisms of Oocyte Aging

作　　者：张江琳 袁海宁 张云洁 李恒兵 苑丽华(审校) 孙振高[2] ZHANG Jiang-lin;YUAN Hai-ning;ZHANG Yunjie;LI Heng-bing;YUAN Li-hua;SUN Zhen-gao(The First Clinical College,Shandong University of Chinese Medicine,Jinan 250014,China;Department of Reproduction and Genetics,The Affiliated Hospital of Shandong University of Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东中医药大学附属医院生殖与遗传科

出　　处：《国际生殖健康/计划生育杂志》2025年第2期144-149,共6页Journal of International Reproductive Health/Family Planning

基　　金：国家重点研发计划(2022YFC3500403);国家自然科学基金(82274572);山东省重点研发计划(2023CXGC010505)。

摘　　要：卵巢衰老是女性衰老的开始,不仅关系到女性生殖健康,也是当前社会低生育力的重要影响因素。目前针对女性生殖衰老的机制已经从多个层次进行了广泛的研究,包括细胞水平、分子水平、系统水平以及个体水平等方面。从线粒体功能、染色体、氧化应激、能量代谢以及免疫因素等方面综述卵母细胞衰老过程中所涉及的多种生物学机制,并探索针对女性生殖衰老靶向治疗的进展,以期为预防卵巢早衰甚至延缓生殖衰老提供重要思路。Ovarian aging is the beginning of female aging,which not only relates to women′s reproductive health but also serves as an important influencing factor of the low fertility rate in the nowadays society.Currently,the mechanisms of female reproductive aging have been extensively studied from multiple levels,including cellular,molecular,systemic and individual levels.This review summarizes various biological mechanisms involved in oocyte aging,such as mitochondrial function,chromosomes,oxidative stress,energy metabolism and immune factors.It also explores the progress of targeted therapies for female reproductive aging,aiming to provide important insights for preventing premature ovarian failure and even delaying reproductive aging.

关 键 词：卵母细胞 衰老 染色体 线粒体 氧化性应激 能量代谢 免疫因素 

分 类 号：R711[医药卫生—妇产科学]