糖皮质激素药代动力学与类固醇耐药型肾病综合征的研究进展  

Research Advances in Glucocorticoid Pharmacokinetics and Steroid-Resistant Nephrotic Syndrome

作　　者：梁宇贤 朱洪涛 LIANG Yuxian;ZHU Hongtao(College of Pediatrics,Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]新疆医科大学儿科学院,新疆乌鲁木齐830000

出　　处：《延边大学医学学报》2025年第2期10-13,共4页Journal of Medical Science Yanbian University

摘　　要：肾病综合征是多种原发性或继发性慢性肾小球疾病的临床表现,是由受损的肾小球基底膜对血清蛋白通透性增加而引起的,其临床表现为蛋白尿、低蛋白血症、外周水肿,常伴有高脂血症。糖皮质激素作为原发性肾病综合征的一线治疗药物,根据激素治疗效果,原发性肾病综合征可分为类固醇敏感型和类固醇耐药型,这种差异是由于个体对糖皮质激素的药代动力学和药效学差异所致,接下来文章就糖皮质激素作用的分子机制和药代动力学进行阐述,为临床个性化医疗提供指导。Nephrotic syndrome represents clinical manifestations of various primary or secondary chronic glomerular diseases,caused by increased permeability of serum proteins through the damaged glomerular basement membrane.Its clinical features include proteinuria,hypoalbuminemia,peripheral edema,and frequently accompanied by hyperlipidemia.As first-line therapeutic agents for primary nephrotic syndrome,glucocorticoids lead to classification of the condition into steroid-sensitive and steroid-resistant types based on therapeutic response.This therapeutic dichotomy stems from interindividual variations in glucocorticoid pharmacokinetics and pharmacodynamics.This article systematically elaborates the molecular mechanisms of glucocorticoid action and pharmacokinetic characteristics,aiming to provide guidance for clinical personalized medicine.

关 键 词：肾病综合征 激素抵抗 分子机制 

分 类 号：R97[医药卫生—药品]