联合应用依诺肝素钠与地屈孕酮治疗复发性流产的临床效果观察  

Clinical Efficacy of Combined Enoxaparin Sodium and Dydrogesterone in the Treatment of Recurrent Miscarriage

作　　者：姚捷 文婷婷 李坪原 YAO Jie;WEN Tingting;LI Pingyuan(Department of Obstetrics,Zunyi First People's Hospital,Zunyi 563000,China)

机构地区：[1]遵义市第一人民医院产科,贵州遵义563000

出　　处：《延边大学医学学报》2025年第2期29-31,共3页Journal of Medical Science Yanbian University

摘　　要：目的:探讨依诺肝素钠联合地屈孕酮治疗复发性流产的疗效。方法:回顾性分析2022年1月—2023年12月在遵义市第一人民医院诊治的96例复发性流产患者临床资料。按不同治疗方法分为对照组和联合组,每组48例。对照组单独使用地屈孕酮治疗,联合组联合使用依诺肝素钠和地屈孕酮治疗。比较两组的妊娠结局、凝血功能指标及胎儿生长发育情况。结果:联合组的妊娠成功率、活产率高于对照组(P <0.05),流产率低于对照组(P <0.05);联合组治疗后的D-二聚体、纤维蛋白原水平低于对照组(P <0.05),凝血酶原时间长于对照组(P <0.05);联合组的胎儿体重、新生儿各个时间的Apgar评分均高于对照组(P <0.05)。结论:在复发性流产的治疗中,联合应用依诺肝素钠与地屈孕酮,可促进患者凝血功能改善,有助于提升妊娠成功率,优化妊娠结局。Objective:To investigate the therapeutic efficacy of combined enoxaparin sodium and dydrogesterone in recurrent miscarriage.Methods:Clinical data of 96 patients with recurrent miscarriage treated at Zunyi First People’s Hospital from January 2022 to December 2023 were retrospectively analyzed.Patients were divided into a control group(48 cases,treated with dydrogesterone alone)and a combined group(48 cases,treated with enoxaparin sodium and dydrogesterone).Pregnancy outcomes,coagulation function indices,and fetal growth were compared between the two groups.Results:The combined group exhibited higher rates of pregnancy success and live births,along with a lower miscarriage rate compared to the control group(P<0.05).Post-treatment levels of D-dimer and fibrinogen in the combined group were lower,while prothrombin time was longer than in the control group(P<0.05).Additionally,the combined group showed higher fetal weight and Apgar scores at all neonatal time points(P<0.05).Conclusion:The combination of enoxaparin sodium and dydrogesterone improves coagulation function,enhances pregnancy success rates,and optimizes pregnancy outcomes in patients with recurrent miscarriage.

关 键 词：复发性流产 依诺肝素钠 地屈孕酮 凝血功能 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]