地塞米松辅助抗菌药物治疗对儿童难治性化脓性脑膜炎脑脊液白细胞计数、降钙素原及预后的影响  

Effects of Dexamethasone Combined with Antimicrobial Therapy on Cerebrospinal Fluid Leukocyte Count,Procalcitonin,and Prognosis in Children with Refractory Purulent Meningitis

作　　者：赵冰 胡庆岩 丁周志 ZHAO Bing;HU Qingyan;DING Zhouzhi(The First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China)

机构地区：[1]蚌埠医科大学第一附属医院,安徽蚌埠233004

出　　处：《延边大学医学学报》2025年第2期114-116,共3页Journal of Medical Science Yanbian University

摘　　要：目的:观察地塞米松辅助抗菌药物治疗儿童难治性化脓性脑膜炎的效果。方法:将2015年1月至2023年10月蚌埠医科大学第一附属医院收治的84例难治性化脓性脑膜炎患儿依据用药方法的不同分为对照组和观察组,各42例。对照组予以抗菌药物治疗,观察组在抗菌药物治疗基础上予以地塞米松辅助治疗,均治疗7 d。比较两组临床疗效、脑脊液相关指标、临床恢复及预后情况。结果:观察组治疗总有效率、预后良好率高于对照组(P<0.05),体温、脑脊液、意识恢复时间及住院时间较对照组短(P<0.05);治疗后观察组降钙素原(PCT)水平、白细胞计数(WBC)、中性粒细胞/淋巴细胞比值(NLR)低于对照组(P<0.05)。结论:地塞米松辅助抗菌药物治疗儿童难治性化脓性脑膜炎疗效显著,可减轻炎症,促进疾病恢复,改善患儿预后。Objective:To observe the efficacy of dexamethasone combined with antimicrobial therapy in children with refractory purulent meningitis.Methods:Eighty-two children with refractory purulent meningitis admitted to The First Affiliated Hospital of Bengbu Medical College from January 2015 to October 2023 were divided into a control group and an observation group(42 cases each)based on treatment methods.The control group received antimicrobial therapy alone,while the observation group received additional dexamethasone.Both groups were treated for 7 days.Clinical efficacy,cerebrospinal fluid(CSF)parameters,recovery time,and prognosis were compared.Results:The observation group showed a higher total effective rate(TER)and good prognosis rate compared to the control group(P<0.05).Recovery times for body temperature,CSF normalization,consciousness,and hospitalization were significantly shorter in the observation group(P<0.05).Post-treatment levels of procalcitonin(PCT),white blood cell count(WBC),and neutrophil-to-lymphocyte ratio(NLR)were significantly lower in the observation group(P<0.05).Conclusion:Dexamethasone combined with antimicrobial therapy significantly improves outcomes in children with refractory purulent meningitis by reducing inflammation,accelerating recovery,and enhancing prognosis.

关 键 词：难治性化脓性脑膜炎 地塞米松 预后 

分 类 号：R72[医药卫生—儿科]