Causal Relationship between PECAM-1 Level and Cardiovascular Diseases:A Mendelian Randomization Study  

作　　者：Mingze Sun Yiming Zhong Gaoxiang Li Yichao Zhao Hengyuan Zhang Xiaoqiu Yang Xiaoxiang Yan Alex F.Chen Jun Pu 

机构地区：[1]Department of Cardiology,State Key Laboratory of Systems Medicine for Cancer,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China [2]Department of Cardiovascular Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [3]Institute for Developmental and Regenerative Cardiovascular Medicine,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

出　　处：《Cardiovascular Innovations and Applications》2024年第1期572-583,共12页心血管创新与应用(英文)

基　　金：supported by grants from the Ministry of Science and Technology of China(2021YFA0804803 and 2022YFA1104204);National Natural Science Foundation of China(82421001,82230014,81930007,81470389,81500221,81930012,and 82241027);the National Science Fund for Distinguished Young Scholars(81625002);Shanghai Municipal Health Commission(2022JC013,2023ZZ02021,and GWVI-11.1-26);Shanghai Municipal Education Commission(SHSMU-ZDCX20210700);Shanghai Hospital Development Center(SHDC12022102);the Science and Technology Commission of Shanghai Municipality(22JC1402100 and 22DZ2292400);the Major Project of Natural Science Foundation of Hunan Province(Open Competition 2021JC0002).

摘　　要：Background:Platelet endothelial cell adhesion molecule(PECAM-1)is present in the vascular endothelium and plays important roles in various biological processes.Several recent studies have reported associations between PECAM-1 and certain subtypes of cardiovascular diseases(CVDs).However,further research is necessary to clarify the causal effects of PECAM-1 on CVDs.To determine whether PECAM-1 and CVDs are causally associated,we conducted a two-sample Mendelian randomization(TSMR)study.Methods:Single nucleotide polymorphisms(SNPs)associated with PECAM-1 were used as instrumental variants(IVs)to estimate the causal effects of PECAM-1 on CVDs.Six SNPs were included in our TSMR study.The inverse-variance weighted(IVW)method was applied in the primary analysis.To confirm the initial results,we conducted several complementary analyses and pleiotropy analyses.Results:In the IVW analysis,higher genetically predicted PECAM-1 levels were associated with lower risk of coronary artery disease(CAD)(OR,0.835;CI,0.757–0.92;P=3×10-4)and myocardial infarction(MI)(OR,0.79;CI,0.709–0.881;P=2.03×10-5).Conclusions:The findings confirmed that elevated PECAM-1 levels may decrease the risk of CAD and MI.These results confirm the causal effect of PECAM-1 on CVDs and may facilitate further investigation of the mechanism of PECAM-1 in CVD pathogenesis.

关 键 词：PECAM-1 cardiovascular diseases Mendelian randomization causal association single nucleotide polymorphism genome wide association study risk factor coronary artery disease myocardial infarction 

分 类 号：R54[医药卫生—心血管疾病]