Angiography-Based Computational Modeling for In Vivo Assessment of Endothelial Dynamic Strain in Coronary Arteries with De Novo Lesions:Comparison of Treatment Effects of Drug-Coated Balloons Between Small and Large Arteries  

作　　者：Lei Xu Zhouhao Tang He Zou Yiqiu Jiang Youxian Shen Xinmin Zhang Ahmed Elkoumy Xueqiang Guan Lianpin Wu Xinlei Wu 

机构地区：[1]Zhejiang-Ireland Joint Laboratory for Precision Diagnosis and Treatment of Valvular Heart Diseases,The Second Afffliated Hospital of Wenzhou Medical University,Wenzhou,China [2]Department of Cardiology,Key Laboratory of Panvascular Diseases of Wenzhou,The Second Afffliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China [3]Department of Radiology,The Second Afffliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China [4]Islamic Center of Cardiology,Al-Azhar University,Cairo,Egypt [5]Discipline of Cardiology,Saolta Group,Galway University Hospital,Health Service Executive,Galway,Ireland [6]CORRIB Core Lab,University of Galway,Galway,Ireland

出　　处：《Cardiovascular Innovations and Applications》2024年第1期616-627,共12页心血管创新与应用(英文)

基　　金：supported by the Zhejiang Provincial Natural Science Foundation of China(LTGY24H180019);Basic Medical and Health Science Technology Projects of Wenzhou City(Y20220132);Medical and Health Science and Technology Project of Zhejiang Province(2023RC210 and 2024KY160).

摘　　要：Acute morphological changes in de novo coronary lesions after drug-coated balloon(DCB)angioplasty can affect endothelial mechanics and consequently clinical outcomes.Angiography-based computational modeling has been validated to assess endothelial dynamic strain(EDS)in coronary arteries in vivo.The EDS was calculated on the basis of pre-and post-DCB angiography.Parameters of quantitative coronary angiography and EDS were quantified at cross-sections in the treated segments.A total of 336 and 348 lesion cross-sections were included in the small/large vessel groups,respectively.The acute lumen gain after DCB was significantly higher in large than small vessels(relative changes:21.3%[17.4%,25.1%]vs.7.4%[4.8%,10.1%],P<0.001).Before treatment,three indices of EDS were significantly higher in small than large vessels(for ED-EDS:29.2%[19.8%,44.8%]vs.20.4%[14.3%,30.2%];for ES-EDS:26.8%[18.9%,37.7%]vs.18.3%[13.9%,25.4%];for TA-EDS:19.1%[13.9%,27.8%]vs.14.3%[10.5%,20.1%],P<0.001).After treatment,the EDS in small vessels significantly decreased(P<0.001).ED-EDS showed the highest correlation with pre-DCB DSP(r=0.43,P<0.001)and post-DCB MLD(r=0.35,P<0.001).The levels of EDS parameters for small or large vessel lesions significantly differed.Further study is required to examine the clinical value of EDS in predicting cardiac events after DCB treatment.

关 键 词：computational modeling coronary angiography endothelial dynamic strain drug-coated balloon de novo lesion 

分 类 号：R541.4[医药卫生—心血管疾病]