Angiotensin-converting Enzyme Inhibitors Decrease the Risk of Cardiac Rupture after Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials  

作　　者：Siyi Li Jinan Wang Yan Yan Wei Gong Shaoping Nie 

机构地区：[1]Center for Coronary Artery Disease,Division of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing,China [2]Beijing Institute of Heart,Lung,and Blood Vessel Diseases,Beijing,China [3]Department of Cardiovascular Medicine,Peking University Third Hospital,Beijing,China

出　　处：《Cardiovascular Innovations and Applications》2023年第1期304-314,共11页心血管创新与应用(英文)

基　　金：This study was supported by the National Natural Science Foundation of China(81970292,82270258 and 82100260);Natural Science Foundation of Beijing,China(7222046 and 7191002);Interdisciplinary Cooperation Project of Beijing Nova Program(Z211100002121165);National Key Research&Development Program of China(2020YFC2004800).

摘　　要：Background:ACEI therapy decreases mortality in patients with acute MI.However,the effects of ACEIs on CR are unclear.Methods:Acomprehensive search of PUBMED,EMBASE,ISI Web of Science,MEDLINE and the Cochrane Regis-ter of Controlled Trials before July 2022 was conducted to identify all RCTs on ACEIs that recorded CR as an outcome.Review Manager 5.3 was used to analyze the data.Results:Five RCTs including 26,383 patients with MI were identified;71 of the 13,159 patients receiving ACEIs and 107 of the 13,224 control patients were verified to have CR.ACEI therapy started within 24 hours after the onset of acute MI significantly decreased the risk of CR,by 33%(RR:0.67,95%CI:0.50–0.90,P=0.008).Conclusions:Early administration of ACEIs(within 24 hours after the onset of acute MI)decreased the incidence of CR in patients with acute MI.

关 键 词：angiotensin-converting enzyme inhibitors cardiac rupture myocardial infarction RCTS META-ANALYSIS 

分 类 号：R54[医药卫生—心血管疾病] R541.4[医药卫生—内科学]