Clinical Relevance of Uric Tobacco-Specific Nitrosamine and Severe Abdominal Aortic Calcification in a National Survey of the United States  

作　　者：Fang Wang Jingang Zheng 

机构地区：[1]Department of Cardiology,China-Japan Friendship Hospital,Beijing,China

出　　处：《Cardiovascular Innovations and Applications》2023年第1期678-688,共11页心血管创新与应用(英文)

基　　金：This work was funded by grants from the National Natural Science Foundation of China(number:81700411);National High Level Hospital Clinical Research Funding&Elite Medical Professionals Project of China-Japan Friendship Hospital(number:ZRJY2021-QM05);Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine(number:2021-QNRC2-A02);National Key Clinical Specialty Construction Project of China(number:2020-QTL-009).

摘　　要：Background:This cross-sectional study is the first investigation of the relationships among uric tobacco-specific nitrosamine(TSNA),N′-nitrosonornicotine(NNN),and abdominal aortic calcification(AAC)in adults in the United States.Methods:The final sample(2713 participants 40 years of age and older)was obtained from the National Health and Nutrition Examination Survey(NHANES)2013–2014.The risk of severe AAC according to uric NNN,the dose–response relationship between uric NNN and severe AAC,and the threshold effect were analyzed with multivariate logistic regression models,a cubic spline model,and a two-piecewise linear regression model,respectively.Results:In the fully adjusted model,the odds ratio(and 95%confidence interval)of severe AAC for participants in the high uric NNN group with respect to the low uric NNN group was 2.39(1.59–3.61)(P<0.001).After adjustment for multiple covariates,the risk of severe AAC increased 1.515-fold for every 1 ng/dL increase in uric NNN when the concentration of uric NNN was below 1.354 ng/dL.The association between uric NNN and severe AAC was stable among various subgroups.Conclusion:In a sample of United States civilians,uric NNN levels positively correlated with the risk of severe AAC.

关 键 词：Cigarette smoking Tobacco-specific nitrosamine N′-nitrosonornicotine Abdominal aortic calcification Cross-sectional study National Health and Nutrition Examination Survey 

分 类 号：R543.1[医药卫生—心血管疾病]