肺动脉内皮细胞在肉鸡腹水综合征中的作用及miRNA调控机制的研究进展  

Research Progress on the Role of Pulmonary Artery Endothelial Cells in Broiler Ascites Syndrome and the Regulation Mechanism of miRNA

作　　者：蒋晨晰 程素芳 吴国灶 陈娟 高晓娜[1] 郭小权[1] 刘平[1] JIANG Chenxi;CHENG Sufang;WU Guozao;CHEN Juan;GAO Xiaona;GUO Xiaoquan;LIU Ping(College of Animal Science and Technology,Jiangxi Agricultural University,Nanchang 330045,China;Jiangxi Biotechnology Vocational College,Nanchang 330200,China;Nanchang Animal Disease Prevention and Control Centre,Nanchang 330000,China)

机构地区：[1]江西农业大学动物科学技术学院,南昌330045 [2]江西生物科技职业学院,南昌330200 [3]南昌市动物疫病预防控制中心,南昌330000

出　　处：《中国畜牧兽医》2025年第4期1522-1532,共11页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金青年科学基金项目(32460906);江西省自然(青年)科学基金项目(20224BAB205033);江西省教育厅科学技术研究项目(22Y08)。

摘　　要：肉鸡腹水综合征是一种由多病因引发的营养代谢性疾病,与遗传、饲养管理、营养失衡及环境等因素均有关。自该病首次出现以来,已给全球家禽养殖业带来了严重经济损失。研究表明,系统性缺氧是肉鸡发生腹水的重要原因,长时间缺氧会导致肺动脉内皮细胞(PAECs)受到损伤,引发其功能紊乱,产生大量血管活性因子刺激血管平滑肌异常收缩,进而加剧血管内皮的异常增殖、炎症反应和表型转化的发生。随着时间的推移,这些变化将导致血管膜增厚、管腔逐渐变窄等复杂病理过程,进而促进了肺动脉重构,最终成为腹水形成的直接诱因。miRNA作为表观遗传调控因子,在调节多种信号传导通路进而影响细胞生理功能方面发挥着不可忽视的作用。在肺动脉高压的形成中,miRNA的作用尤为显著,参与调控肺动脉内皮细胞的生理过程。鉴于此,笔者探讨了肉鸡腹水综合征的病因及其发病机制,阐明了肺动脉内皮细胞的功能变化以及miRNA在这一复杂疾病过程中的关键作用,以期为肉鸡腹水综合征的预防和控制提供参考。Broiler ascites syndrome is a nutritional metabolic disease caused by multiple etiology,which is related to heredity,feeding management,nutritional imbalance and environment.Since its first appearance,the disease has caused serious economic losses to the global poultry industry.Research indicates that systemic hypoxia is an important cause of ascites in broilers.Prolonged hypoxia can lead to the injury of pulmonary artery endothelial cells(PAECs),resulting in functional disorders,excessive production of vasoactive factors,abnormal contraction of vascular smooth muscles,and exacerbation of abnormal proliferation,inflammatory responses,and phenotypic transformation of vascular endothelium.Over time,these changes will lead to complex pathological processes such as the thickening of the vascular media and the gradual narrowing of the lumen,which will promote pulmonary artery remodeling and eventually become the direct inducement of ascites formation.As epigenetic regulatory factors,miRNA plays an important role in regulating various signal transduction pathways and thus affecting cell physiological functions.In the formation of pulmonary hypertension,miRNA plays a particularly significant role in regulating the physiological process of pulmonary artery endothelial cells.Consequently,the author discussed the etiology and pathogenesis of broiler ascites syndrome,clarified the functional changes of pulmonary artery endothelial cells and the key role of miRNA in this complex disease process,in order to provide reference for the prevention and control of broiler ascites syndrome.

关 键 词：肉鸡腹水综合征 肺动脉内皮细胞(PAECs) 肺动脉高压 MIRNA 

分 类 号：S856.5[农业科学—临床兽医学]