异荭草素的生物学功能研究进展  

Research Progress on the Biological Functions of Isoorientin

作　　者：罗通旺 金研 盛燚凡 王书杰 宋厚辉 邵春艳 LUO Tongwang;JIN Yan;SHENG Yifan;WANG Shujie;SONG Houhui;SHAO Chunyan(China-Australia Joint Laboratory for Animal Health Big Data Analytics,Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management,Zhejiang Provincial Engineering Laboratory for Animal Health Inspection&Internet Technology,Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province,College of Animal Science and Technology/College of Veterinary Medicine of Zhejiang A&F University,Hangzhou 311300,China)

机构地区：[1]浙江农林大学动物科技学院/动物医学院,浙江省畜禽绿色生态健康养殖应用技术研究重点实验室,动物健康互联网检测技术浙江省工程实验室,动物医学与健康管理浙江省国际科技合作基地,中澳动物健康大数据分析联合实验室,杭州311300

出　　处：《中国畜牧兽医》2025年第4期1579-1589,共11页China Animal Husbandry & Veterinary Medicine

基　　金：浙江农林大学科研发展基金人才启动项目(2020FR045);浙江农林大学学生科研训练项目。

摘　　要：异荭草素又称异荭草苷,是一种天然的黄酮类化合物,具有广泛的生物学活性和药理作用,主要存在于荞麦、麻花艽、人字草、千屈草和荭草等植物。已有的研究表明,异荭草素具有改善骨质疏松、治疗糖尿病、抗抑郁、抗肿瘤以及减轻脏器损伤等多种功效,而其作用机制主要是通过抗氧化应激、抗炎和调控细胞凋亡来实现,作用过程中所涉及的关键蛋白包括核因子E2相关因子2(Nrf2)、核因子激活的B细胞κ-轻链增强复合物(NF-κB)、丝裂原活化蛋白激酶(MAPK)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、胞内磷脂酰肌醇激酶(PI3K)、蛋白激酶B(Akt)、血红素氧合酶-1(HO-1)等。此外,异荭草素的研究目前主要以实验鼠和相关细胞系为对象进行急性毒性和亚急性毒性试验,缺乏畜禽等其他动物或细胞的基础试验,这在一定程度上影响了异荭草素的产品开发和临床应用。作者综述了异荭草素生物学功能的研究进展,并对其在临床上的应用提出展望,以期为异荭草素生物学活性的进一步研究以及拓展其在临床上的应用提供新思路和理论支撑。Isoorientin is a natural flavonoid plant compound with a wide range of biological activities and pharmacological effects.In nature,isoorientin mainly exists in many plants,such as Fagopyrum esculentum Moench,Gentiana straminea Maxim,Kummerowia striata(Thunb.)Schindl,Lythrum salicaria L and Polygonum orientale L.Previous studies have shown that isoorientin has multiple effects such as improving osteoporosis,treatment of diabetes,antidepressant,anti-tumor,and reducing organ damage.Its mechanism of action is mainly achieved through the biological activities of antioxidant stress,anti-inflammatory,and regulation of cell apoptosis.The key proteins involved in this process include nuclear factor E2-related factor 2(Nrf2),nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB),mitogen-activated protein kinase(MAPK),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),phosphatidylinositide 3-kinases(PI3K),protein kinase B(Akt),heme oxygenase-1(HO-1),etc.In addition,current research on isoorientin mainly focuses on acute and subacute toxicity tests on rats,mice and related cell lines,lacking basic experiments on other animals or cells such as livestock and poultry,which to some extent affects the product development and clinical application of isoorientin.This article reviewed the functional activity of isoorientin,and proposes prospects for its clinical application,in order to provide new ideas and theoretical support for further research on the biological activity of isoorientin and expand its clinical application.

关 键 词：异荭草素 抗氧化 抗炎 细胞凋亡调控 

分 类 号：S816.7[农业科学—饲料科学]