circRNA在猪脂肪沉积调控中的研究进展  

Research Progress on circRNA Regulating Fat Deposition in Pigs

作　　者：何晓菲 雷宇航 朱砺[1,2] 甘麦邻 沈林園 HE Xiaofei;LEI Yuhang;ZHU Li;GAN Mailin;SHEN Linyuan(State Key Laboratory of Swine and Poultry Breeding Industry,Sichuan Agricultural University,Chengdu 611130,China;Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province,Sichuan Agricultural University,Chengdu 611130,China)

机构地区：[1]四川农业大学,猪禽种业全国重点实验室,成都611130 [2]四川农业大学,畜禽遗传资源发掘与创新利用四川省重点实验室,成都611130

出　　处：《中国畜牧兽医》2025年第4期1627-1638,共12页China Animal Husbandry & Veterinary Medicine

基　　金：四川省科技计划(2021ZDZX0008、2021YFYZ0030、sccxtd-2024-08-09);国家生猪产业技术体系(CARS-35)。

摘　　要：脂肪沉积能力是影响猪瘦肉率、屠宰率及肉品质的重要因素之一,而脂肪沉积的调控机制涉及复杂的生物学过程,其中非编码RNA(non-coding RNA,ncRNA)这类表观遗传调节因子扮演着关键角色。环状RNA(circular RNA,circRNA)是真核生物中存在的一种共价闭合的环状ncRNA,具有相对保守性和时空特异性,作用途径丰富多样,并广泛参与细胞增殖和凋亡、基因转录、癌症发生、神经系统疾病等各类生物学过程。近年来,越来越多的研究表明,circRNA对于猪皮下、肌内和内脏脂肪的沉积有着重要调控作用,但大部分研究还处于发现和鉴定的起步阶段,很多circRNA上、下游通路的具体机制尚不清晰。目前来看,circRNA主要通过miRNA的分子海绵机制来控制脂肪沉积相关基因的表达,影响脂质代谢,促进或抑制脂肪细胞的增殖分化,调控猪的脂肪沉积。作者在概述脂肪组织的分类与功能、调控脂肪沉积的关键基因、circRNA的生物发生及功能的基础上,系统回顾并总结了国内外circRNA调控猪脂肪沉积的研究进展,以期为进一步探究猪脂肪沉积的机制提供参考。Fat deposition ability is one of the important factors affecting the lean meat rate,slaughter rate and meat quality of pigs,and the regulatory mechanism of fat deposition involves complex biological processes,among which epigenetic regulators such as non-coding RNA(ncRNA)play a key role.Circular RNA(circRNA)is a covalently closed circular ncRNA existing in eukaryotes,it is relatively conservative and spatiotemporally specific,with rich and diverse action pathways,and is widely involved in various biological processes such as cell proliferation and apoptosis,gene transcription,cancer occurrence and nervous system diseases.In recent years,more and more studies have shown that circRNA plays an important regulatory role in the deposition of subcutaneous,intramuscular and visceral fat in pigs,but most studies are still in the initial stage of discovery and identification,and the specific mechanisms of many upstream and downstream pathways of circRNA are still unclear.At present,circRNA mainly controls the expression of fat deposition-related genes through the molecular sponge mechanism of miRNA,affects lipid metabolism,promotes or inhibits the proliferation and differentiation of adipocytes,and regulates fat deposition in pigs.Based on an overview of the classification and function of adipose tissue,key genes regulating fat deposition,and the biogenesis and function of circRNA,this paper systematically reviews and summarizes the research progress on circRNA regulating fat deposition of pigs at home and abroad,in order to provide a reference for further exploration of the mechanism of pig fat deposition.

关 键 词：猪 circRNA 脂肪沉积 

分 类 号：S828[农业科学—畜牧学] Q78[农业科学—畜牧兽医]