生物信息学在黄曲霉毒素B_(1)毒性机制研究中的应用  

Application of Bioinformatics in Toxicity Mechanism of Aflatoxin B_(1)

作　　者：刘晓童 葛冰洁 邱谦 刘馨蔓 于明弘 张雪梅[1] LIU Xiaotong;GE Bingjie;QIU Qian;LIU Xinman;YU Minghong;ZHANG Xuemei(Agricultural College of Yanbian University,Yanji 133002,China)

机构地区：[1]延边大学农学院,延吉133002

出　　处：《中国畜牧兽医》2025年第4期1639-1650,共12页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金项目(32360900、32060817);吉林省自然科学自由探索重点项目(YDZJ202401430ZYTS)。

摘　　要：黄曲霉毒素B_(1)(aflatoxin B_(1),AFB_(1))是一种天然毒素,广泛存在于食品和动物饲料中,具有很强的急性毒性、致畸性、致突变性和致癌性等,对人和动物健康构成了巨大风险。动物摄入AFB_(1)污染的饲料可引起免疫抑制、繁殖障碍、脏器损伤甚至大规模死亡,对畜牧业造成极大的经济损失。此外,AFB_(1)通过饲料转移到肉、蛋、奶等动物源性食品中,最终通过食物链进入人体内,引起急性或慢性中毒,危害人类健康。生物信息学是一门融合了计算机科学、生物学和统计学的交叉学科,通过结合多领域研究方法对生物信息进行获取、处理、分析和解释。生物信息学分析方法包括网络毒理学、转录组学、蛋白质组学和代谢组学等,是目前生命科学领域研究的前沿技术,也是阐明毒物毒性机制的重要工具和手段。作者对生物信息学在AFB_(1)毒性作用机制中的应用进行综述,旨在为防治AFB_(1)中毒及生物信息学的应用提供有效途径和理论依据。Aflatoxin B_(1)(AFB_(1))is a kind of natural toxin,widely found in food and animal feed,with strong acute toxicity,carcinogenicity,teratogenicity and mutagenicity,posing a huge risk to human and animal health.Animal ingestion of AFB_(1)-contaminated feed causes immunosuppression,reproductive disorders,organ damage and even large-scale death,causing great economic losses to the animal husbandry industry.In addition,AFB_(1) is transferred to animal-derived foods such as meat,eggs and milk through feed,and eventually enters the human body through the food chain,causing acute or chronic poisoning and endangering human health.Bioinformatics is an interdisciplinary discipline that integrates computer science,biology and statistics,and obtains,processes,analyzes and interprets biological information through a combination of multi-field research methods.Bioinformatics analysis methods,including network toxicology,transcriptomics,proteomics and metabolomics are the cutting-edge technologies in the field of life sciences and an important tool and technique to elucidate the mechanism of toxicity.The authors focuse on the application of bioinformatics in the mechanism of AFB_(1) toxicity,aiming to provide an effective approach and theoretical basis for the prevention and treatment of AFB_(1) poisoning and the application of bioinformatics.

关 键 词：黄曲霉毒素B_(1) 生物信息学 毒性机制 转录组学 代谢组学 

分 类 号：S852.44[农业科学—基础兽医学]