微生物转录因子工程的研究进展  

Research Advances in Microbial Transcription Factor Engineering

作　　者：梁志慧 陆孔泳 郑洋洋 王智文 LIANG Zhihui;LU Kongyong;ZHENG Yangyang;WANG Zhiwen(School of Life Sciences,Ningxia University,Yinchuan 750021,China;School of Chemical Engineering,Tianjin University,Tianjin 300350,China)

机构地区：[1]宁夏大学生命科学学院,宁夏银川750021 [2]天津大学化工学院,天津300350

出　　处：《宁夏大学学报(自然科学版中英文)》2025年第1期59-67,共9页Journal of Ningxia University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(NSFC-22278312);宁夏回族自治区中央引导地方科技发展专项基金资助项目(2024FRD05057);宁夏重点研发基金资助项目(2024BEE02005)。

摘　　要：随着合成生物学的快速发展,微生物细胞工厂成为绿色生物制造的重要方式.转录因子工程作为一种通过转录因子来调控基因表达的技术,具有可同时调控代谢途径的多个基因的功能,在微生物代谢工程和合成生物学研究中发挥着重要作用.介绍转录因子及其调控机制,综述当前微生物中转录因子的研究进展和转录因子工程的应用进展等,讨论转录因子工程面临的挑战和未来发展趋势.With the rapid development of synthetic biology,microbial cell factories have emerged as a pivotal platform for green biomanufacturing.Transcription factor engineering,a technology that utilizes transcription factors to regulate gene expression,enables simultaneous modulation of multiple genes within metabolic pathways.This approach plays a crucial role in microbial metabolic engineering and synthetic biology research.This review introduces the fundamental concepts and regulatory mechanisms of transcription factors,summarizes recent advances in microbial transcription factor studies and their engineering applications,and discusses current challenges and future directions in this field.

关 键 词：转录因子 转录因子工程 调控机制 耐受性 生物传感器 

分 类 号：Q78[生物学—分子生物学]