Orchestrating the Phytochemical Content and Bioactivities in the Leaf,Bark,and Fruit Extracts of Cornus capitata Wall  

作　　者：Deen Bandhu Dimri Manisha Nigam Naresh Singh Shilpa Semwal Marcello Iriti Abhay Prakash Mishra 

机构地区：[1]Department of Biochemistry,Hemvati Nandan Bahuguna Garhwal University,Srinagar Garhwal,Uttarakhand,246174,India [2]Department of Biomedical,Surgical and Dental Sciences,University of Milan,via L.Vanvitelli 32,Milan,20129,Italy [3]National Interuniversity Consortium of Materials Science and Technology,via G.Giusti 9,Firenze,50121,Italy [4]Cosmetics and Natural Products Research Center(CosNat),Faculty of Pharmaceutical Sciences,Naresuan University,Phitsanulok,65000,Thailand

出　　处：《Phyton-International Journal of Experimental Botany》2025年第3期1007-1027,共21页国际实验植物学杂志(英文)

摘　　要：Cornus capitata,commonly known as the Himalayan strawberry,is a dogwood species from the family Cornaceae.Dogwood plants have been used extensively to practice conventional medicine due to their biological activities;however,the mechanisms behind these activities,particularly in C.capitata,remain largely unexplored.This study focuses on the preliminary phytochemical screening,antioxidant activity,anti-diabetic potential,and antimicrobial profiling of different extracts(i.e.,leaves,bark,and fruit)from C.capitata to evaluate its potential pharmaceutical and medicinal applications.The in-vitro antioxidant activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl(DPPH)scavenging assay,Ferric-reducing antioxidant power(FRAP)assay,and Superoxide Anion Scavenging assay.The anti-diabetic potential was assessed usingα-Glucosidase,α-Amylase,and Pancreatic lipase inhibition assay.The anti-microbial activity was evaluated using the Kirby-Bauer method and Minimal Inhibitory Concentration(MIC).According to the quantitative investigation,the most substantial quantities of flavonoids and phenolic compounds were identified in the leaves of C.capitata.Antioxidant activity results corroborated this conclusion,demonstrating that methanolic leaf extract had strong antioxidant activity,with the lowest IC_(50) values recorded for the DPPH(32.4±0.19µg/mL)and Superoxide Radical Scavenging(37.10±0.21µg/mL)assays.Furthermore,the methanolic leaf extract displayed the highestα-Glucosidase inhibitory potential(IC_(50)=6.09±0.52µg/mL),while the methanolic bark extract exhibited the highestα-Amylase inhibitory activity(IC_(50)=49.10±0.38µg/mL).Regarding antimicrobial potential,the paper disc diffusion assay showed that none of the extracts demonstrated antibacterial effects against E.coli.However,the MIC assay revealed that the leaves and bark extracts exhibited antibacterial properties with MIC values of 80 and 500µg/mL against E.coli,respectively.The paper disc diffusion assay against C.albicans indicated the antimicrobial poten

关 键 词：Cornus capitata PHYTOCHEMICAL antioxidant Α-GLUCOSIDASE α-Amylase antimicrobial 

分 类 号：R28[医药卫生—中药学]