可溶性α-Klotho的生物学功能及肾脏保护作用的可能机制  

Biological function of solubleα‐Klotho and its protective mechanism against renal injury

作　　者：张燕[1,2] 廖晖[2] 覃志成 李荣山[1,3,4] Zhang Yan;Liao Hui;Tan Zhicheng;Li Rongshan(Department of Nephrology,Heping District of Shanxi Provincial People's Hospital(the Fifth Clinical Medical College of Shanxi Medical University),Taiyuan 030000,China;National Drug Clinical Trial Institution,Shanxi Provincial People's Hospital(the Fifth Clinical Medical College of Shanxi Medical University),Taiyuan 030000,China;Medicinal Basic Research Innovation Center of Chronic Kidney Disease of the Ministry of Education,Shanxi Medical University,Taiyuan 030001,China;School of Pharmacy,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西省人民医院(山西医科大学第五临床医学院)和平院区肾内科,太原030000 [2]山西省人民医院(山西医科大学第五临床医学院)国家药物临床试验机构,太原030000 [3]教育部慢性肾脏病医药基础研究创新中心(山西医科大学),太原030001 [4]山西医科大学药学院,太原030001

出　　处：《中华肾脏病杂志》2025年第1期63-69,共7页Chinese Journal of Nephrology

基　　金：山西省基础研究计划项目(20210302124612);山西省人民医院博士科研启动金项目(b202346);山西省中医药管理局科研课题(2024ZYY2B037);教育部慢性肾脏病医药基础研究创新中心(山西医科大学)专项基金(CKD/SXMU-2024-04)。

摘　　要：α-Klotho蛋白是由Klotho基因编码的一种抗衰老蛋白,主要在肾小管以Ⅰ型膜蛋白(膜结合型)形式存在。膜结合型α-Klotho蛋白的细胞外结构域可被切割并分泌到体循环中,被称为可溶性α-Klotho,可溶性α-Klotho为目前体液中可检测出的主要形式。该文主要综述了可溶性α-Klotho在肾脏中的生物学功能及其肾保护作用的分子生物学机制,并对可溶性α-Klotho在各类肾脏疾病中的作用及α-Klotho对其他器官的作用进行概述。Theα‐Klotho protein is an anti‐aging protein encoded by the Klotho gene and mainly exists in the renal tubules in the form of type 1 membrane protein(membrane-boundform).The extracellular domain of the membrane-boundα‐Klotho protein can be cleaved and secreted into the circulation,which is called solubleα‐Klotho.Solubleα‐Klotho is the main form that can be detected in the body fluid.This paper mainly reviews the biological functions of solubleα‐Klotho in the kidney and its possible molecular biological mechanisms,and also summarizes the role of solubleα‐Klotho in various kidney diseases and the effects ofα‐Klotho on the other organs.

关 键 词：肾疾病 分子生物学 细胞保护 可溶性α-Klotho 作用机制 

分 类 号：R69[医药卫生—泌尿科学]