铁基磁共振造影剂的研究进展  

Progress in studying iron-based magnetic resonance contrast agents

作　　者：郭泽沛 杨仕平 GUO Zepei;YANG Shiping(College of Chemistry and Materials Science,Shanghai Normal University,Shanghai 200234,China)

机构地区：[1]上海师范大学化学与材料科学学院,上海200234

出　　处：《上海师范大学学报(自然科学版中英文)》2025年第1期43-52,共10页Journal of Shanghai Normal University(Natural Sciences)

基　　金：国家自然科学基金(91959105)。

摘　　要：近年来,铁基磁共振造影剂因其优良的磁学特性和良好的生物相容性,在医学成像领域中得到了广泛关注.通过对铁基磁共振造影剂进行配体修饰,可以赋予其特异性靶向功能,从而显著提高对特定或病变组织的成像精度.这种靶向功能的提升不仅优化了成像质量,还增强了对病变的早期检测和准确诊断能力.结合多模态成像技术,铁基造影剂可以与计算机断层扫描(CT)、正电子发射断层成像(PET)等成像手段互补,提供更为全面和精准的病理信息,为临床提供了更丰富的诊断依据.同时,成像引导治疗作为一种前沿技术,通过实时监测和反馈,进一步提高了治疗的精确性和效果.文章总结了铁基磁共振造影剂的最新研究进展,探讨其在靶向成像、多模态融合以及成像引导治疗中的应用前景,并展望了未来的发展方向.In recent years,iron-based magnetic resonance contrast agents have received widespread attention in the medical imaging field due to their excellent magnetic properties and good biocompatibility.By modifying iron-based contrast agents with ligands,specific targeting functions can be endowed,significantly enhancing the imaging precision for specific or diseased tissues.The improvement in targeting capability not only optimizes imaging quality,but also enhances the early detection and accurate diagnosis of lesions.Combined with multimodal imaging techniques,iron-based contrast agents can complement imaging methods such as computed tomograph(CT)and positron emission tomography(PET),providing more comprehensive and precise pathological information and a richer basis for clinical diagnosis.Additionally,image-guided therapy,as a cuttingedge technology,further improves the precision and effectiveness of treatment through real-time monitoring and feedback.This review will summarize the latest research progress of iron-based contrast agents,explore their application prospects in targeted imaging,multimodal fusion,and image-guided therapy,and give a prospect for future development directions.

关 键 词：铁基磁共振造影剂 磁共振成像(MRI) 肿瘤治疗 多模态成像 

分 类 号：O614.81[理学—无机化学] R318.6[理学—化学]