锰(Ⅱ)基造影剂在磁共振成像中的研究进展  

Research progress of manganese(Ⅱ)-based contrast agents in magnetic resonance imaging

作　　者：张何仙 杨仕平 ZHANG Hexian;YANG Shiping(College of Chemistry and Materials Science,Shanghai Normal University,Shanghai 200234,China)

机构地区：[1]上海师范大学化学与材料科学学院,上海200234

出　　处：《上海师范大学学报(自然科学版中英文)》2025年第1期53-61,共9页Journal of Shanghai Normal University(Natural Sciences)

基　　金：国家自然科学基金(91959105)。

摘　　要：磁共振成像(MRI)是一种非侵入性分子成像方式,在临床诊断中发挥着重要作用.非镧系金属锰(Mn)在细胞生物学中至关重要,是早期报道的用于MRI的顺磁性造影剂示例之一.文章综述了锰(Ⅱ)基造影剂在MRI中的研究进展,介绍了MRI基本原理与造影剂作用,以及详述了各类锰(Ⅱ)基造影剂优缺点、合成方法,及在生物医学领域的应用.重点讨论了锰(Ⅱ)基造影剂的性能优化策略及其在临床应用中面临的挑战,并对其未来的发展趋势进行了展望.Magnetic resonance imaging(MRI)is a non-invasive molecular imaging modality,which plays an important role in clinical diagnosis.Non-lanthanide metal manganese(Mn)is of vital importance in cell biology and is one of the early reported examples of paramagnetic contrast agents used for MRI.This paper reviews the research progress of manganese(Ⅱ)-based contrast agents in MRI,introduces the basic principles of MRI and the role of contrast agents,elaborates on the advantages and disadvantages,synthetic methods,and biomedical applications of diverse manganese(Ⅱ)-based contrast agents.The performance optimization strategies of manganese(Ⅱ)based contrast agents and the challenges they face in clinical applications were discussed in detail,and their future development trends were also prospected.

关 键 词：磁共振成像(MRI) 锰(Ⅱ)基造影剂 肿瘤诊断 肿瘤治疗 

分 类 号：O614.33[理学—无机化学]