慢性持续期哮喘中医证素与临床特征的相关性分析  

Correlation Analysis Between Traditional Chinese Medicine Syndrome Elements and Clinical Characteristics of Chronic Persistent Asthma

作　　者：张正易 王钰 陈林锦 李翠[1] 邱磊 吴定中[1] 郑培永[1] 崔洁 鹿振辉[1] ZHANG Zhengyi;WANG Yu;CHEN Linjin;LI Cui;QIU Lei;WU Dingzhong;ZHENG Peiyong;CUI Jie;LU Zhenhui(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《中国中医基础医学杂志》2025年第3期481-486,共6页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金项目(82274429);上海市卫生健康委项目(2022XD027,20234Z0018)。

摘　　要：目的 通过探讨慢性持续期哮喘患者的证素分布特点及其与临床特征的关系,为临床诊疗及科学研究提供客观依据。方法 收集2020年1月至2021年11月上海中医药大学附属龙华医院门诊150例慢性持续期支气管哮喘患者的中医证素信息和临床资料,分析中医证素的分布情况,以及中医证素与哮喘控制测试(ACT)评分、呼出气一氧化氮(Fe NO)、第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占预计值百分比(FEV1%)、第1秒用力呼气容积与用力肺活量比(FEV1/FVC)、中性粒细胞百分比(NEUT%)、嗜酸性粒细胞百分比(EOS%)、单核细胞百分比(MONO%)的相关性。结果 慢性持续期哮喘患者的病位证素主要集中于肺,共出现123例(82.00%),其次分别为表(24.67%)、心(17.33%)、肾(15.33%)和脾(8.00%)。病性证素中气虚出现的频率最高,为68例(45.33%),其次为阳虚(44.00%)、痰(38.67%)和血虚(24.00%)。病位证素中表与Fe NO呈正相关(R=0.165,P=0.015),脾、肾与FEV1、FEV1%,FEV1/FVC等肺功能指标呈负相关(P<0.05)。病性证素中痰与ACT评分呈负相关(R=-0.186,P=0.010),气虚、阳虚、血虚、阴虚与EOS%呈负相关(P<0.05),气虚、血虚、阴虚亦与FEV1呈负相关(P<0.05)。结论 慢性持续期哮喘和肺、脾、肾关系紧密,主要病性证素为气虚、阳虚、痰等,且主要证素与临床特征存在相关性。Objective To explore the distribution characteristics of TCM syndrome elements in patients with chronic persistent asthma and their relationship with clinical characteristics,which provides objective basis for diagnosis,treatment,and scientific research.Methods 150 patients with chronic persistent asthma in the Longhua Hospital,Shanghai University of Traditional Chinese Medicine from January,2020 to November,2021 were selected as the research objects.Their TCM syndrome elements and clinical data were collected.The distribution of TCM syndrome elements was analyzed,as well as the correlation between TCM syndrome elements and ACT score,FeNO,FEV1,FEV1%,FEV1/FVC,NEUT%,EOS%,and MONO%.Results The main location syndrome elements of chronic persistent asthma is lung,which exists in 123 cases(82.00%),followed by exterior(24.67%),heart(17.33%),kidney(15.33%),and spleen(8.00%).The highest frequency in syndrome elements is Qi deficiency,which exists in 68 cases(45.33%),followed by Yang deficiency(44.00%),phlegm(38.67%),and blood deficiency(24.00%).There is a positive correlation between the exterior and FeNO(R=0.165,P=0.015),while the spleen and kidney are negatively correlated with lung function such as FEV1,FEV1%,and FEV1/FVC(P<0.05).For syndrome elements,there is a negative correlation between phlegm and ACT score(R=-0.186,P=0.01).Qi deficiency,Yang deficiency,blood deficiency and Yin deficiency are negatively correlated with the EOS%(P<0.05).Qi deficiency,blood deficiency and Yin deficiency are also negatively correlated with FEV1(P<0.05).Conclusion Chronic persistent asthma is closely related to the lung,spleen,and kidney.The main TCM syndrome elements are Qi deficiency,Yang deficiency,phlegm,etc.And there is a correlation between the main syndrome elements and clinical characteristics.

关 键 词：慢性持续期哮喘 相关性 证素 临床特征 

分 类 号：R259[医药卫生—中西医结合]