定向多孔结构壳聚糖药物载体材料的构建  

Construction of Chitosan with Oriented Porous Structure for Drug Carrier

作　　者：奚晓玮 陈诚[1,2] 高闻语 刘子睿 王东煜 张传蕾 邓林红[1,2,3] 刘杨 XI Xiaowei;CHEN Cheng;GAO Wenyu;LIU Zirui;WANG Dongyu;ZHANG Chuanlei;DENG Linhong;LIU Yang(School of Medical and Health Engineering,Changzhou University,Changzhou 213164,Jiangsu,China;School of Pharmacy&School of Biological and Food Engineering,Changzhou University,Changzhou 213164,Jiangsu,China;Institute of Biomedical Engineering&Health Sciences,Changzhou University,Changzhou 213164,Jiangsu,China)

机构地区：[1]常州大学医学与健康工程学院,江苏常州213164 [2]常州大学药学院生物与食品工程学院,江苏常州213164 [3]常州大学生物医学工程与健康科学研究院,江苏常州213164

出　　处：《功能高分子学报》2025年第2期148-156,共9页Journal of Functional Polymers

基　　金：国家自然科学基金(81900814)。

摘　　要：基于温度变化过程对高分子构象的作用,通过调控冰晶生长过程制备了径向孔径呈梯度变化的壳聚糖支架材料(CS-RC)。研究表明:在低温环境下,支架材料的外缘区域的温度梯度差大于内核区域的温度梯度差,通过进一步调控冰晶的生长过程,实现了壳聚糖支架内部孔隙结构呈规则的梯度分布,孔径分布在100~140µm。理化性能评价结果表明,CS-RC支架具有良好的保湿性能、力学性能以及稳定的降解性能,并且孔隙率能达到88.8%左右。此外,相对于传统的低温冻干壳聚糖支架材料,CS-RC支架的载药率显著提高,对亲水性药物阿仑膦酸钠的载药率和包封率分别提高了8.4%、15.9%,对疏水性药物利福平的载药率和包封率分别提高了4.8%、11.5%,药物在支架中呈现出稳定的缓释过程和有效释放周期。Chitosan(CS)scaffolds(CS-RC)with radially gradient changes in pore size were prepared by modulating the ice crystal growth process,based on the role of temperature changes on polymer conformation.Results show that the temperature gradient difference in the outer edge region is larger than that in the inner core region at low temperatures,and thus,modulation of the ice crystal growth process can achieve a regular,controlled morphology distribution of the internal pore structure of the CS-RC scaffolds,with pore diameters ranging from 100μm to 140μm.The physicochemical performance evaluation results indicate that the CS-RC scaffolds possess good moisturizing properties and mechanical properties,stable degradation properties,and a high porosity of about 88.8%.Additionally,compared to traditional low-temperature lyophilized chitosan scaffold materials,the CS-RC scaffolds exhibit a significant increase in drug loading rates and encapsulation rates,increasing by 8.4%and 15.9% for the hydrophilic drug alendronate,and 4.8% and 11.5% for the hydrophobic drug rifampicin,respectively.The drugs also show a stable sustained-release process and an effective,sustained release cycle within the scaffolds.

关 键 词：壳聚糖 多孔支架 冷冻干燥 冰晶生长 药物载体 

分 类 号：Q819[生物学—生物工程]