Targeting anti-virulence factor strategies of bacterial pathogens  

作　　者：Jiashu Li Tianyuan Jia Liang Yanag 

机构地区：[1]Shenzhen National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,The Second Affiliated Hospital of Southern University of Science and Technology,Shenzhen518112,China [2]Department of Pharmacology,Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases,School of Medicine,Southern University of Science and Technology,Shenzhen518000,China

出　　处：《Biosafety and Health》2025年第1期1-4,共4页生物安全与健康(英文)

基　　金：supported by the Science Technology and Innovation Commission of Shenzhen(JCYJ20210324115607021);the National Natural Science Foundation of China(32300068,32270196,91951204,32200155,32200053,and 32300060).

摘　　要：Antibiotic-resistant bacterial pathogens pose substantial biosafety and health hazards,leading to millions of deaths each year.The evolution of bacterial virulence factors is mainly propelled by horizontal gene transfer(HGT).In addition to traditional antibiotics,antimicrobial strategies targeting biofilm-related virulence factors and quorum sensing(QS)-related virulence factors can effectively restrain drug-resistant bacteria.Future antivirulence strategies,encompassing natural drugs,antibiotic resistance inhibitors,monoclonal antibodies(mAbs),and vaccines,are in the development pipeline.Consequently,by disrupting virulence factors,these drugs can eliminate the ability of bacterial pathogens to cause disease.In conclusion,this Perspective comprehensively summarizes current anti-bacterial virulence factor strategies and prospects for future cutting-edge approaches,which may address the issues of antibacterial resistance and curtail the spread of pathogens in the future.

关 键 词：Irulence factors Horizontal gene transfer Anti-biofilm strategies Quorum-sensing(Qs) 

分 类 号：R446.5[医药卫生—诊断学]