Epidemiological characteristics of human adenovirus infections in China,2020-2023  

作　　者：Chongyang Li Yitong Lin Naiying Mao Yixuan Gao Ying Liu Liwei Sun Hui Zhang Jin Xu Maozhong Li Feng Zhang Xiaoqing Liu Linqing Zhao Bing Zhu Ye Chen Min Mu Xiaoling Tian Hongmei Xu Chaoyang Huang Zhong Li Jing Xu Zhenguo Gao Yali Jin Chunyu Zhu Aili Cui Baicheng Xia Yan Zhang Zhen Zhu 

机构地区：[1]National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing102206,China [2]Precision Medicine Research Center,Children's Hospital of Changchun,Changchun 130061,China [3]Gansu Provincial Center for Disease Control and Prevention,Key Laboratory of Infectious Diseases of Gansu Province,Lanzhou 730050,China [4]Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016,China [5]Institute for Immunization and Prevention,Bejing Center for Disease Prevention and Control,Academy for Preventive Medicine,Institute of Tuberculosis Control Research and Prevention,Bejing100013,China [6]Laboratory of Viral Diseases,Qingdao Municipal Centre for Disease Control and Prevention,Qingdao Institute of Prevention Medicine,Qingdao 266000,China [7]Jiangxi Provincial Center for Disease Control and Prevention,Nanchang 330029,China [8]Laboratoyof Virology,Bejing Key Laboratoryf Etogyof Viral iseases in Children,Capital Insttuteof Pediatrics,Bejing100020,China [9]Virus Laboratory,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510120,China [10]Shenyang Center for Disease Control and Prevention,Shenyang City,Shenyang 110100,China [11]School of Public Health,Anhui University of Science and Technology,Huainan231131,China [12]Institute for Immunization Program,Inner Mongolia Autonomous Region Centre for Disease Control and Prevention,The Academy of Preventive Medicine Sciences in Inner Mongolia Autonomous Region,Hohhot010031,China [13]Departnent of Infection Diseases,Children's Hospital of Chongqing Medical University,Chongqing 400014,China [14]Hunan Provincial Centre for Disease Control and Prevention,Changsha 410153,China [15]Shandong Center for Disease Prevention and Control,Shandong Provincial Key Laboratory of Intelligent Monitoring,Early Warning,Prevention and Control for Infectious Diseases,Jinan 250014,China [16]Shaanxi Provincial Centre

出　　处：《Biosafety and Health》2025年第1期26-32,共7页生物安全与健康(英文)

基　　金：supported by the National Key R&D Program of China(2022YFC2305303).

摘　　要：To better understand the epidemiological characteristics of human adenovirus(HAdv)infections in China during and after the coronavirus disease 2019(COvVID-19)pandemic,respiratory specimens were collected from 17,562 enrolled patients with acute respiratory infections(ARIs)in 14 sentinel surveillance provinces during 2020-2023.Eight common respiratory viruses were detected using commercially available nucleic acid detection kits.HAdV-positive cases were statistically analyzed for detection rates,geographic distribution,seasonal patterns,demographic characteristics,and co-infection status.The results of this study showed that the overall HAdV detection rate was 5.09%(894/17,562)during 2020-2023,with a gradual decrease in the annual detection rate from 6.66%in 2020 to 3.89%in 2022 and a rebound in 2023(5.19%).The overall HAdV detection rate was significantly higher in the southern region(6.15%)than in the northern region(4.76%)(P<0.001).The median age of patients with HAdv infection was 3 years,with infants aged 0-2 years accounting for the majority(41.39%).HAdV-positive cases were detected throughout the year,with no clear seasonal pattern,and the HAdV epidemic in China during 2020-2023 may have been driven primarily by the virus infection in the southern region.Co-infections were frequent in HAdV-positive cases(overall rate:36.01%),primarily consisting of dual infections(79.28%),with human rhinovirus and human respiratory syncytial virus being the most common coinfecting pathogens.In conclusion,this study suggested the significant regional and temporal variation in HAdV detection rate in China during 2020-2023,and thus ongoing surveillance should be conducted to elucidate the epidemiological dynamics of HAdV infections.

关 键 词：Respiratory infection Epidemiological characteristic Humana denovirus 

分 类 号：R373[医药卫生—病原生物学]