某三甲医院2021—2024年药品不良反应报告分析  

Analysis of adverse drug reaction reports of a class A hospital in Zhengzhou from 2021 to 2024

作　　者：庞丽[1] 陈永妍[1] PANG Li;CHEN Yong-yan(Department of Pharmacy,the Seventh People’s Hospital of Zhengzhou,Zhengzhou 450016,China)

机构地区：[1]郑州市第七人民医院药学部,郑州450016

出　　处：《医药论坛杂志》2025年第3期312-317,共6页Journal of Medical Forum

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20220851)。

摘　　要：目的了解郑州市第七人民医院药品不良反应(adverse drug reaction,ADR)的发生规律和特点,促进临床安全合理用药。方法对郑州市第七人民医院2021年1月至2024年5月在国家药品不良反应监测系统上报的946例ADR报告,从患者性别和年龄、给药途径、涉及药品种类、ADR累及系统/器官及主要临床表现、ADR报告分级及转归等方面进行统计分析。结果946例ADR报告中,男性患者(546例,57.72%)多于女性患者(400例,42.28%),45~64岁患者最多(414例,43.76%),大于64岁患者次之(289例,30.55%);静脉注射给药途径所致ADR最多(507例,53.59%),其次为口服(380例,40.17%);发生ADR最多的药品种类为心血管系统药物(215例,22.73%),其次为抗感染药物(205例,21.67%);累及系统/器官以皮肤及其附件疾病(251例,21.75%)和胃肠系统疾病(249例,21.58%)为主;163例严重ADR中153例(93.87%)经过对症处理或药物抢救等治疗后好转或痊愈。结论ADR的发生与患者年龄、给药途径和药物种类等因素相关。加强ADR监测,可以降低ADR的发生率,确保患者用药安全。Objective To investigate the occurrence regularity and characteristics of adverse drug reaction(ADR)in a Class A hospital in Zhengzhou,and to promote clinical safe and rational drug use.Methods Totally 946 ADR cases reported by the National Adverse drug Reaction Surveillance System in that hospital from January 2021 to May 2024 were statistically analyzed in terms of gender and age of patients,route of administration,drug types involved,ADR system/organ involved,and main clinical manifestations,classification and clinical outcomes of ADR reports.Results Among the 946 cases of ADR,the proportion of male(546 cases,57.72%)was higher than female(400 cases,42.28%).Most of the patients were 45~64 years old(414 cases,43.76%),followed by patients aged>64 years(289 cases,30.55%).Most ADR were intravenous-related(507 cases,53.59%),followed by oral administration(380 cases,40.17%).Cardiovascular system drugs took the first place(215 cases,22.73%)in ADR.Anti-infective drugs took the second place(205 cases,21.67%)in ADR.The most common system organ class involved were skin and accessories system disorders(251 cases,21.75%)and gastrointestinal disorders(249 cases,21.58%).153 patients(93.87%)were improved or recovered after drug rescue or symptomatic treatment in the 163 patients with serious ADR.Conclusion The occurrence of ADR is related to the patient’s age,administration route,and drug type,etc.Strengthening ADR monitoring can reduce the occurrence of ADR,and ensure safe drug use for patients.

关 键 词：药品不良反应 统计分析 合理用药 用药监测 

分 类 号：R954[医药卫生—药学]