CD4^(+)杀伤性T细胞在自身免疫性疾病中的研究进展  

Research progress of cytotoxic CD4^(+)T cell in autoimmune diseases

作　　者：张芹 迟锐 龚芳 ZHANG Qin;CHI Rui;GONG Fang(Department of Laboratory Medicine,Jiangnan University Medical Center,Wuxi 214002;Department of Pathophysiology,Wuxi School of Medicine,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学附属中心医院检验科,江苏无锡214002 [2]江南大学无锡医学院病理生理教研室,江苏无锡214122

出　　处：《细胞与分子免疫学杂志》2025年第2期161-165,共5页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金面上项目(82270034);无锡市“双百”中青年医疗卫生拔尖人才(BJ2023028);无锡市卫生健康委青年科研项目(Q202304)。

摘　　要：CD4^(+)杀伤性T细胞(cytotoxic CD4^(+)T cells,CD4^(+)CTL)是一类具有细胞毒作用的新T细胞亚群,其通过主要组织相容性复合体Ⅱ(MHC-Ⅱ)依赖、抗原特异性的方式识别靶细胞,分泌具有细胞毒性的颗粒酶、穿孔素和颗粒溶素等作用于靶细胞,从而发挥对靶细胞的毒性作用。近年来发现其在多种自身免疫性疾病中发挥重要作用。本文将围绕CD4^(+)CTL的分化、表型及其在不同类型自身免疫性疾病中的作用进行综述,为相关疾病的防治提供新思路。Cytotoxic CD4^(+)T cells(CD4^(+)CTLs)represent a novel subset of T cells with cytotoxic effects.They recognize target cells in an antigen-specific manner,relying on classⅡmajor histocompatibility complex(MHC-Ⅱ)interactions.CD4^(+)CTLs exert cytotoxic effects on target cells by secreting cytotoxic molecules such as granzymes,perforin,and granulysin.Recent studies have revealed their significant roles in various autoimmune diseases.This review focuses on the differentiation,phenotypic characteristics,and roles of CD4^(+)CTLs in different types of autoimmune disorders,aiming to provide new insights for the prevention and treatment of these diseases.

关 键 词：CD4^(+)杀伤性T细胞 自身免疫性疾病 免疫应答 机制 综述 

分 类 号：R392[医药卫生—免疫学] R593.2[医药卫生—基础医学] R392.11[文化科学—情报学] G353.11