巨噬细胞在腱骨愈合中的作用机制研究进展  

Research progresses on the mechanism of macrophages in tendon bone healing

作　　者：王亮 邓银栓 屈涛 达朝明 贺云飞 刘锐 牛伟民 颜维舜 陈真 李硕 杨志云 郭斌斌 赖学倩 WANG Liang;DENG Yinshuan;QU Tao;DA Chaoming;HE Yunfei;LIU Rui;NIU Weimin;YAN Weishun;CHEN Zhen;LI Shuo;YANG Zhiyun;GUO Binbin;LAI Xueqian(Orthopedics Department,Gansu Provincial Central Hospital,Lanzhou 730070,China;Department 2 of Children’s Emergency Center of Gansu Provincial Central Hospital,Lanzhou 730070,China)

机构地区：[1]甘肃省中心医院骨科,甘肃兰州730070 [2]甘肃省中心医院儿童急救中心二部,甘肃兰州730070

出　　处：《细胞与分子免疫学杂志》2025年第2期183-187,共5页Chinese Journal of Cellular and Molecular Immunology

基　　金：甘肃省自然科学基金资助项目(18JR3RA077)。

摘　　要：肌腱与骨骼的连接部位称为腱骨连接,随着全民运动意识不断提高,运动过量及暴力极易对其造成损伤。腱骨愈合是一个涉及多因素的复杂修复和愈合过程,良好的腱骨愈合是发挥其生理功能的先决条件。腱骨结构的复杂性也给腱骨损伤的修复带来了巨大的挑战,近年来研究发现,干细胞、生长因子、巨噬细胞等与腱骨损伤后的愈合过程有密切的联系,其中巨噬细胞在腱骨愈合过程中发挥重要的作用。笔者查阅近几年相关研究文献,就巨噬细胞在腱骨愈合中的作用展开综述,以期为促进腱骨愈合的治疗策略提供新的思路和方向。The connection between tendons and bones is called the tendon bone connection.With the continuous improvement of national sports awareness,excessive exercises and the related intensity are prone to damage the tendon bone connection.Tendon bone healing is a complex repair and healing process involving multiple factors,and good tendon bone healing is a prerequisite for its physiological function.The complexity of tendon bone structure also poses great challenges to the repair of tendon bone injuries.In recent years,researches have found that stem cells,growth factors,macrophages,and other factors are closely related to the healing process of tendon bone injuries,among which macrophages play an important role in the healing process.The authors reviewed relevant research literature in recent years and summarized the role of macrophages in tendon bone healing,in order to provide new ideas and directions for treatment strategies to promote tendon bone healing.

关 键 词：腱骨愈合 巨噬细胞 机制 综述 

分 类 号：R681.5[医药卫生—骨科学] G353.11[医药卫生—外科学]