高血压肾损害的诊治  

Diagnosis and treatment of hypertensive nephropathy

作　　者：刘佳仪 蔡广研 LIU Jia-yi;CAI Guang-yan(Department of Nephrology,the First Medical Center,Chinese PLA General Hospital/State Key Laboratory of Kidney Diseases/National Clinical Research Center for Kidney Diseases,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院第一医学中心肾脏病医学部、肾脏疾病全国重点实验室、国家慢性肾病临床医学研究中心,北京100853

出　　处：《中国实用内科杂志》2025年第3期194-198,共5页Chinese Journal of Practical Internal Medicine

基　　金：北京市科技计划课题(D181100000118004)。

摘　　要：高血压肾损害是以肾脏细小动脉玻璃样变和(或)肾小动脉肌内膜肥厚为主要病理学改变,进而导致肾小球和肾小管缺血性病变的一组临床综合征。研究发现,高血压和肾损害之间并非简单的因果关系,研究其发病机制有助于预防疾病发生和延缓进展。高血压肾损害是终末期肾脏疾病(ESRD)的主要病因之一,结合临床指标和病理学改变进行早期诊断和干预具有重要意义。应在全面评估后通过生活方式改善、药物治疗等综合方案以改善患者远期预后。Hypertensive nephropathy is a kind of clinical syndrome mainly manifested by arteriolar hyalinosis and intimal thickening of/or small arterioles,which in turn leads to ischemic lesions of glomeruli and tubules.Studies have found that it is not a simple cause-and-effect relationship between hypertension and renal damage,and the study of its pathogenesis can help to prevent the disease from occurring and slow down its progression.Hypertensive nephropathy is one of the major causes of end-stage renal disease,and it is of great significance to combine clinical indicators with pathological changes for early diagnosis and intervention.A combination of lifestyle improvement with drug therapy should be adopted after comprehensive evaluation to improve the long-term prognosis.

关 键 词：高血压肾损害 慢性肾脏病 

分 类 号：R5[医药卫生—内科学]