《补体相关性肾病诊断和治疗专家共识》要点解读  

Interpretation of Expert consensus on the diagnosis and treatment of complement-related kidney diseases

作　　者：谭颖[1] 赵明辉[1] TAN Ying;ZHAO Ming-hui(Renal Division,Department of Medicine,Peking University First Hospital/Institute of Nephrology,Peking University,Beijing 100034,China)

机构地区：[1]北京大学第一医院肾内科北京大学肾脏病研究所,北京100034

出　　处：《中国实用内科杂志》2025年第3期237-240,共4页Chinese Journal of Practical Internal Medicine

基　　金：首都卫生发展科研专项(首发2024-2-4076);北京市自然科学基金面上项目(7242143)。

摘　　要：随着对于补体在各类肾脏疾病中的作用机制的深入认识,针对补体活化不同环节的药物相继出现,已有证据显示补体靶向治疗在补体相关性肾病中具有良好的应用前景。《补体相关性肾病诊断和治疗专家共识》于2024年发布,围绕补体相关性肾病的发病机制、诊断思路、补体靶向治疗与特殊致病微生物的疫苗免疫等方面进行了推荐,强调根据补体系统在不同肾脏疾病发病机制中的作用合理应用补体抑制剂。该文就该共识的要点进行阐述,以期改善补体相关性肾病的临床实践。With the in-depth understanding of the role of complement in various kidney diseases,medications targeting different components of complement activation have been emerging.Evidence suggests that complement-targeted therapies hold promising potential in the treatment of complement-related kidney diseases."Expert Consensus on the Diagnosis and Treatment of Complement-Related Kidney Diseases"published in 2024 provides recommendations on the pathogenesis,diagnostic approaches,complement-targeted therapies,and vaccination against specific pathogenic microorganisms concerning complement-related kidney diseases,and emphasizes the rational application of complement inhibitors accroding to different roles of complment system in the pathogenesis of certain kidney diseases.This article highlights the key points of the consensus,aiming to improve clinical practice in managing complement-related kidney diseases.

关 键 词：补体相关性肾病 补体靶向治疗 专家共识 

分 类 号：R5[医药卫生—内科学]