蛋白质生物标志物超灵敏检测技术的研究进展  

Research Progress in Ultrasensitive Detection Technologies for Protein Biomarkers

作　　者：王海涛[1,2,3] 马晓媛 宋艳冰 王雨萱 王亚斐 赵琢 张拥军 WANG Hai-tao;MA Xiao-yuan;SONG Yan-bing;WANG Yu-xuan;WANG Ya-fei;ZHAO Zhuo;ZHANG Yong-jun(School of Pharmacy,Tianjin Polytechnic University,Tianjin 300387,China;Cangzhou Institute of Tianjin Polytechnic University,Hebei Provincial Membrane Industry Technology Research Institute,Cangzhou 061019,China)

机构地区：[1]天津工业大学化学学院,天津300387 [2]沧州市天津工业大学沧州研究院,沧州061019 [3]河北省膜产业技术研究院,沧州061019

出　　处：《离子交换与吸附》2025年第1期46-63,共18页Ion Exchange and Adsorption

基　　金：国家自然科学基金重点项目(基金号52033004);天津工业大学沧州研究院第二批孵化与产业化项目(基金号TGCYY-F-0203);河北省自然科学基金面上项目(基金号E2023110007);沧州市重点研发计划指导项目(基金号222107007)。

摘　　要：蛋白质生物标志物作为疾病分子诊断的重要依据,对早期诊断、疾病分期及治疗效果评估具有重要价值。文章综述了蛋白质生物标志物超灵敏检测技术的研究进展,介绍了常见的蛋白质生物标志物的超灵敏检测技术,特别探讨了基于分子印迹聚合物和纳米技术构建的生物传感器在蛋白质生物标志物超灵敏检测中的应用,这些传感器在检测蛋白质生物标志物方面展现出了高灵敏度和高特异性。此外,文章还讨论了蛋白质生物标志物超灵敏检测面临的挑战,并对未来的发展方向进行了展望。This article reviews the research progress of ultrasensitive detection techniques for protein biomarkers.Protein biomarkers,serving as important evidence for molecular diagnosis of diseases,are of great value for early diagnosis,disease staging,and evaluation of treatment efficacy.The article introduces common ultrasensitive detection techniques for protein biomarkers,with a particular focus on the application of biosensors constructed based on molecularly imprinted polymers and nanotechnology in the ultrasensitive detection of protein biomarkers.These sensors have demonstrated high sensitivity and specificity in detecting protein biomarkers.In addition,the article also discusses the challenges faced in the ultrasensitive detection of protein biomarkers and looks ahead to the future development directions.

关 键 词：疾病早期诊断 生物标志物 蛋白质超灵敏检测 生物传感器 

分 类 号：R34[医药卫生—基础医学]