乙氧羰基卟啉锌的合成及光动力抗菌活性研究  

Synthesis and Photodynamic Antibacterial Activity of Zinc Ethoxycarbonyl Porphyrin

作　　者：黄婉瑜 蒋俊豪 梁惠婷 林佳颖 莫雅通 郭铿炜 余玉莲 谢烯婷 史蕾[1] 佘婷婷 张召 HUANG Wanyu;JIANG Junhao;LIANG Huiting;LIN Jiaying;MO Yatong;GUO Kengwei;YU Yulian;XIE Xiting;SHI Lei;SHE Tingting;ZHANG Zhao(College of Chemistry and Materials Science,Guangdong University of Education,Guangzhou 510303,China;College of Biological Food Engineering,Guangdong University of Education,Guangzhou 510303,China;Department of Biochemistry and Molecular Biology,Guangdong Medical University,Zhanjiang 524023,China)

机构地区：[1]广东第二师范学院化学与材料科学学院,广东广州510303 [2]广东第二师范学院生物与食品工程学院,广东广州510303 [3]广东医科大学生物化学与分子生物学教研室,广东湛江524023

出　　处：《山东化工》2025年第5期34-38,共5页Shandong Chemical Industry

基　　金：大学生创新创业训练计划项目(202314278008、S202414278025);广东省科技创新战略专项资金(pdjh2023b0387);国家自然科学基金青年项目(82003786);广东省科技厅基础与应用基础研究基金项目(2019A1515110338);佛山市第四人民医院高水平医院建设登峰计划(FSYKF-2020012);广东省本科高校教学质量与教学改革工程建设项目——有机化学实验教研室项目、广东第二师范学院-广州云通锂电池股份有限公司锂离子电池校企联合实验室项目(No.XQSYS-2222873)。

摘　　要：卟啉作为一种良好的光敏剂,在光动力治疗领域具有广泛的应用前景。本文以5,10,15,20-四(乙氧羰基)卟啉(TECP)为先导化合物,与醋酸锌配位合成了5,10,15,20-四(乙氧基羰基)卟啉锌(Zn-TECP)。通过紫外-可见吸收光谱、荧光发射光谱、核磁共振氢谱及高分辨质谱等表征了TECP和Zn-TECP的结构;以铜绿假单胞菌细菌为实验对象,采用涂布法接种菌种,测定了两种化合物的最低杀菌浓度(MBC)和最低抑菌浓度(MIC)值。研究结果表明,有光照条件下,Zn-TECP的MBC和MIC值均为64μg/mL,比TECP低,具有更好的光动力抗菌性能。As a good photosensitizer,porphyrin has a wide application prospect in the field of photodynamic therapy.In this paper,5,10,15,20-tetra-(ethoxycarbonyl)porphyrin zinc(Zn-TECP)was synthesized by the coordination of 5,10,15,20-tetra-(ethoxycarbonyl)porphyrin ligands(TECP)with zinc acetate.The structures of TECP and Zn-TECP were characterized by ultraviolet visible optical absorption spectroscopy,fluorescence emission spectra,1H nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry.The minimum bactericidal concentration(MBC)and minimum inhibitory concentration(MIC)of the two compounds were determined by smear method with Pseudomonas aeruginosa as experimental subject.The results showed that the MBC and MIC values of Zn-TECP were both 64μg/mL under the condition of light,which was lower than TECP and had better photodynamic antibacterial property.

关 键 词：光动力治疗 卟啉 锌 酯基 抗菌 

分 类 号：O614.81[理学—无机化学]