2型糖尿病患者不同糖化血红蛋白水平分层与尿微量白蛋白的相关性研究  

Correlation between Stratified Glycated Hemoglobin Levels and Urinary Microalbumin in Patients with Type 2 Diabetes Mellitus

作　　者：黄旭开 梁勋杭 Huang Xukai;Liang Xunhang(Department of Endocrinology,Wuzhou Workers'Hospital,Wuzhou 543000,Guangxi Zhuang Autonomous Region,China;Laboratory Department,Wuzhou Workers'Hospital,Wuzhou 543000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]梧州市工人医院内分泌科,广西壮族自治区梧州543000 [2]梧州市工人医院检验科,广西壮族自治区梧州543000

出　　处：《中外医药研究》2025年第7期24-26,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：广西壮族自治区卫生健康委自筹经费科研项目(编号:Z-D20231653)。

摘　　要：目的:探讨2型糖尿病患者不同糖化血红蛋白(HbA_(1c))水平分层与尿微量白蛋白(mAlb)的相关性。方法:选取梧州市工人医院内分泌科2022年1月—2023年1月收治的2型糖尿病患者311例,根据HbA_(1c)水平分为4组,其中A组(n=80)HbA_(1c)≤8.60%,B组(n=76)HbA_(1c)>8.60%~10.65%,C组(n=84)HbA_(1c)>10.65%~12.80%,D组(n=71)HbA_(1c)>12.80%。对比4组一般资料及mAlb水平。结果:4组mAlb水平比较,差异有统计学意义(P<0.001);Spearman相关性分析显示,不同HbA_(1c)水平与mAlb呈正相关(P<0.001),线性回归方程:mAlb=-67.788+9.123×HbA_(1c);D组肾功能衰竭时间估算值为18.804,低于总体水平。结论:2型糖尿病患者HbA_(1c)水平与mAlb呈正相关,应加强患者的血糖控制,以延缓肾脏损伤,保护肾功能。Objective:To investigate the correlation between stratified glycated hemoglobin(HbA_(1c))levels and urinary microalbumin(mAlb)in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 311 T2DM patients admitted to Endocrinology Department of Wuzhou Workers'Hospital from January 2022 to January 2023 were enrolled and divided into four groups based on HbA_(1c) levels:group A(n=80)with HbA_(1c)≤8.60%,group B(n=76)with HbA_(1c)>8.60% to 10.65%,group C(n=84)with HbA_(1c)>10.65% to 12.80%,and Group D(n=71)with HbA_(1c)>12.80%.General data and mAlb levels were compared among the groups.Results:Significant differences in mAlb levels were observed among the four groups(P<0.001).Spearman correlation analysis revealed a positive correlation between HbA_(1c) levels and mAlb(P<0.001),with the linear regression equation:mAlb=-67.788+9.123×HbA_(1c).The estimated time to renal failure in Group D was 18.804,which was lower than the overall level.Conclusion:HbA_(1c) levels are positively correlated with mAlb levels in T2DM patients.Strengthening glycemic control is essential to delay renal injury and protect renal function.

关 键 词：2型糖尿病 糖化血红蛋白 尿微量白蛋白 相关性 

分 类 号：R587.1[医药卫生—内分泌]