血清肝素结合蛋白检测对减少慢性阻塞性肺疾病急性加重期抗生素应用剂量的作用研究  

The Role of Serum Heparin-binding Protein Detection in Reducing Antibiotic Usage During Acute Exacerbations of Chronic Obstructive Pulmonary Disease

作　　者：李乃庆 Li Naiqing(Department of Respiratory and Critical Care Medicine,Liuzhou Liutie Central Hospital,Liuzhou 545007,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]柳州市柳铁中心医院呼吸与危重症医学科,广西壮族自治区柳州545007

出　　处：《中外医药研究》2025年第7期54-56,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(编号:220200244)。

摘　　要：目的:探讨血清肝素结合蛋白(HBP)检测对减少慢性阻塞性肺疾病急性加重期(AECOPD)抗生素应用剂量的作用。方法:选取2020年7月—2023年1月于柳州市柳铁中心医院接受治疗的64例AECOPD患者作为研究对象,随机分为对照组(医师依据患者临床表现、白细胞计数、肺部CT等决定是否使用抗生素及抗生素使用时间)和观察组(在对照组基础上根据HBP水平开展抗生素治疗),各32例。对比两组抗生素使用情况、临床疗效、住院指标及30 d再入院率。结果:观察组抗生素使用率低于对照组,抗生素使用时间7~10 d占比高于对照组(P<0.05);观察组治疗总有效率高于对照组(P=0.003);观察组住院时间短于对照组,住院费用少于对照组,30 d再入院率低于对照组(P<0.05)。结论:血清HBP检测对减少AECOPD患者抗生素应用有积极作用,能降低抗生素使用比例,缩短抗生素使用时间、住院时间,减少住院费用,提高临床疗效。Objective:To investigate the role of serum heparin-binding protein(HBP)detection in reducing antibiotic usage during acute exacerbations of chronic obstructive pulmonary disease(AECOPD).Methods:Sixty-four AECOPD patients admitted to Liuzhou Liutie Central Hospital from July 2020 to January 2023 were randomly divided into a control group(n=32,antibiotic therapy determined by clinical manifestations,white blood cell count,and chest CT findings)and an observation group(n=32,antibiotic therapy guided by serum HBP levels in addition to conventional evaluation).Antibiotic usage patterns,clinical efficacy,hospitalization parameters,and 30-day readmission rates were compared between groups.Results:The observation group demonstrated significantly lower antibiotic utilization rates and higher proportions of appropriate 7-10 day antibiotic courses compared to the control group(P<0.05).The total response rate was higher than the control group(P=0.003).The observation group was shorter than the control group,the hospitalization cost was less than the control group,and the 30 d readmission rate was lower than the control group(P<0.05).Conclusion:Serum HBP detection effectively reduces unnecessary antibiotic use in AECOPD patients,optimizing treatment duration,improving clinical outcomes,and decreasing healthcare utilization.

关 键 词：慢性阻塞性肺疾病 急性加重期 血清肝素结合蛋白 抗生素 

分 类 号：R563.9[医药卫生—呼吸系统]