维生素AD联合阿莫西林克拉维酸钾序贯疗法治疗小儿反复呼吸道感染的临床效果及安全性研究  

Clinical Efficacy and Safety Study of Vitamin AD Combined with Amoxicillin Clavulanate Potassium Sequential Therapy in the Treatment of Recurrent Respiratory Tract Infections in Children

作　　者：苏秀玲 甘丽君 SU Xiuling;GAN Lijun(Department of Pediatrics,Chongyi County People’s Hospital,Jiangxi Province,Ganzhou,Jiangxi 341300,China)

机构地区：[1]江西省崇义县人民医院儿科,江西赣州341300

出　　处：《中国医药指南》2025年第10期13-15,共3页Guide of China Medicine

基　　金：赣州市指导性科技计划项目(20222ZDX8609)。

摘　　要：目的研究维生素AD联合阿莫西林克拉维酸钾序贯疗法治疗小儿反复呼吸道感染的临床效果及安全性。方法选取江西省崇义县人民医院在2022年12月至2023年11月期间收治的60例反复呼吸道感染患儿按照随机数字表法分为观察组(n=30)和对照组(n=30),两组均需要采取阿莫西林克拉维酸钾序贯疗法治疗,观察组在此基础上采取维生素AD治疗。对比两组的治疗总有效率、临床症状消失时间、炎症指标、不良反应发生情况。结果观察组的治疗总有效率96.67%高于对照组80.00%,差异有统计学意义(P<0.05);经过治疗后的临床症状消失时间观察组短于对照组,WBC、CRP、PCT观察组低于对照组(均P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论在小儿反复呼吸道感染的治疗中,阿莫西林克拉维酸钾序贯疗法联合维生素AD在增强疗效的同时,能改善免疫功能作,且更好地降低炎症指标,缓解临床症状,具有较高的安全性。Objective To study and analyze the clinical efficacy and safety of vitamin AD combined with amoxicillin clavulanate potassium sequential therapy in the treatment of recurrent respiratory tract infections in children.Methods Sixty children with recurrent respiratory tract infection admitted to Chongyi County People’s Hospital of Jiangxi Province from December 2022 to November 2023 were divided into observation group(n=30)and control group(n=30)according to random number table method.Both groups were treated with sequential therapy of amoxicillin and clavulanate potassium,and the observation group was treated with vitamin AD on this basis.The total effective rate,time of clinical symptom disappearance,inflammatory index and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.67%,which was higher than the control group’s 80.00%,and the difference was statistically significant(P<0.05),The disappearance time of clinical symptoms after treatment in the observation group was shorter than that in the control group,and the WBC,CRP,and PCT in the observation group were lower than those in the control group(all P<0.05),There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions In the treatment of recurrent respiratory tract infection in children,amoxicillin and clavulanate potassium sequential therapy combined with vitamin AD can improve immune function,better reduce inflammatory indicators,relieve clinical symptoms,and have high safety.

关 键 词：维生素AD 阿莫西林克拉维酸钾 反复呼吸道感染 安全性 

分 类 号：R725.6[医药卫生—儿科]