长效胰岛素结合口服降糖药对2型糖尿病患者血糖控制效果观察  

Observation of the Effect of Long-Acting Insulin Combined with Oral Hypoglycemic Agents on Blood Glucose Control in Type 2 Diabetes Patients

作　　者：洪阿缘 HONG Ayuan(General Practice,Huli Street Community Health Service Center,Huli District,Xiamen,Fujian 361000,China)

机构地区：[1]厦门市湖里区湖里街道社区卫生服务中心,福建厦门361000

出　　处：《中国医药指南》2025年第10期112-114,共3页Guide of China Medicine

摘　　要：目的分析长效胰岛素、口服降糖药物共同用药在促进2型糖尿病患者血糖控制方面的作用。方法回顾性分析2020年10月至2022年2月厦门市湖里区湖里街道社区卫生服务中心的70例2型糖尿病患者的资料,以抽签法将其分为对照组与干预组,对照组35例经降糖药物口服用药,干预组35例经长效胰岛素和口服降糖药物联合用药,对比两组不良反应发生情况、血糖水平、胰岛素功能及生活质量。结果干预组用药后总不良反应2.86%和对照组8.57%比较,P>0.05。干预组用药后空腹血糖、餐后2 h血糖、糖化血红蛋白水平及胰岛素抵抗指数均较对照组低(均P<0.05)。干预组用药后躯体角色、社会功能、心理健康、精神健康、躯体疼痛、总体健康评价评分,及胰岛β细胞功能指数均较对照组高(均P<0.05)。结论2型糖尿病患者实施常规治疗与联合治疗,对患者病情改善有积极意义,但是较之常规治疗,长效胰岛素结合口服降糖药物治疗的临床干预效果更好,不仅可以进一步调整患者血糖水平,改善其胰岛功能,还能有效提高治疗效果,改善患者的生活质量。Objective To analyze the effect of combined use of long-acting insulin and oral hypoglycemic drugs in promoting the control of blood glucose and blood sugar in type 2 diabetes patients.Methods Retrospective analysis of the data of 70 cases of type 2 diabetes mellitus patients from Huli Street Community Health Service Centre,Huli District,Xiamen City,from October 2020 to February 2022,divided into control group and intervention group by lottery method,35 cases in the control group were orally administered via glucose-lowering drugs,and 35 cases in the intervention group were orally administered via the combination of long-acting insulin and oral glucose-lowering drugs,comparing the incidence of adverse reactions,blood glucose levels,insulin function and quality of life in the two groups.Results The total adverse reactions of 2.86%in the intervention group compared with 8.57%in the control group,P>0.05.Fasting blood glucose,2 h postprandial blood glucose,glycated haemoglobin level and insulin resistance index were lower in the intervention group compared with the control group(all P<0.05).Post-medication somatic role,social functioning,mental health,spiritual health,somatic pain,general health assessment scores,and pancreaticβ-cell function index were higher in the intervention group than in the control group(all P<0.05).Conclusions Routine treatment and combined treatment of type 2 diabetes patients have positive significance for the improvement of patients’condition,but compared with conventional treatment,the clinical intervention effect of long-term insulin combined with oral hypoglycemic drugs is better,which can not only further adjust the patient’s blood glucose level and improve their pancreatic islet function,but also improve the therapeutic efficacy and quality of life of the patients.

关 键 词：长效胰岛素 降糖药物 2型糖尿病 血糖控制效果 胰岛功能 

分 类 号：R587.1[医药卫生—内分泌]