甲巯咪唑片对促甲状腺激素受体抗体过高在甲状腺功能亢进症中的作用  

Effect of drug-based modulation of methimazole tablets on thyroid stimulating hormone receptor antibody overload in hyperthyroidism

作　　者：周祥兵 高文龙 汤彩 ZHOU Xiangbing;GAO Wenlong;TANG Cai(Department of Endocrinology,the People's Hospital of Susong,Anhui,Anqing 246500,China)

机构地区：[1]安徽省宿松县人民医院内分泌科,246500

出　　处：《河北医药》2025年第3期440-443,共4页Hebei Medical Journal

摘　　要：目的分析在甲状腺功能亢进症患者治疗中应用甲巯咪唑片治疗的临床效果及对促甲状腺激素受体抗体(TRAb)的影响。方法纳入2020年1至12月接受治疗的98例甲状腺功能亢进症患者作为研究对象,选择随机数字表法将98例患者均分为对照组和观察组,每组49例。对照组给予丙硫氧嘧啶片进行治疗,观察组给予甲巯咪唑片进行治疗,比较2组临床疗效和用药不良反应,2组治疗前后甲状腺激素水平和甲状腺抗体水平。结果治疗后,观察组总有效率为91.84%,高于对照组的83.67%(χ^(2)=8.214,P<0.05);观察组不良反应总发生率为14.29%,与对照组的18.37%无差异(χ^(2)=0.299,P>0.05);观察组三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、促甲状腺激素(TSH)、游离T3、游离T4、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)和促甲状腺激素受体抗议体(TRAb)均低于对照组,差异有统计学意义(P<0.05)。结论在甲状腺功能亢进症患者治疗中应用甲巯咪唑片治疗的临床效果良好,与丙硫氧嘧啶片相比治疗有效性更好,用药安全性相近,且甲巯咪唑片在调节甲状腺激素水平和甲状腺抗体水平方面效果更佳,值得推广应用。Objective To analyze the clinical effect of methimazole tablets on the treatment of hyperthyroidism and the effect on thyroid receptor antibodies(TRAb).Methods Ninety-eight patients with hyperthyroidism treated from January 2020 to December 2020 were included as study subjects.They were randomly divided into control group(n=49)and observation group(n=49)by a random number table method.Patients in the control group were given propylthiouracil tablets,and those in the observation group were given methimazole tablets.Clinical efficacy,adverse effects of medication,thyroid hormone levels and thyroid antibody levels before and after treatment were compared between the two groups.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group(91.84%vs 83.67%,χ^(2)=8.214,P<0.05).There was no significant difference in the total incidence of adverse events between the observation and control groups(14.29%vs 18.37%,χ^(2)=0.299,P<0.05).Triiodothyronine(T3),thyroxine(T4),thyroid-stimulating hormone(TSH),free T3,free T4,thyroglobulin antibodies(TGAb),thyroid peroxidase antibodies(TPOAb)and TRAb were significantly lower in the observation group than the control group(P<0.05).Conclusion Methimazole tablets are clinically effective in the treatment of hyperthyroidism,with better therapeutic efficacy and similar safety than propylthiouracil tablets.They are more effective in regulating thyroid hormone levels and thyroid antibody levels,which is worth promoting.

关 键 词：甲巯咪唑片 丙硫氧嘧啶片 促甲状腺激素受体抗体 甲状腺功能亢进症 

分 类 号：R581.1[医药卫生—内分泌]