血清小而密低密度脂蛋白胆固醇及炎症细胞因子在老年冠心病患者诊断与预后评估中的临床意义  

Clinical significance of serum small and dense low-density lipoprotein cholesterol and inflammatory cytokines in the diagnosis and prognosis evaluation of elderly patients with coronary heart disease

作　　者：滕飞 周传涛 王志远 TENG Fei;ZHOU Chuantao;WANG Zhiyuan(Department of Laboratory Medicine,Liaocheng Fourth People's Hospital,Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市第四人民医院检验科,山东聊城252000

出　　处：《当代医学》2024年第36期104-107,共4页Contemporary Medicine

摘　　要：目的探究血清小而密低密度脂蛋白胆固醇(small dense low-density lipoprotein cholesterol,sd LDL-C)及炎症细胞因子[白细胞介素-6(interleukin-6,IL-6)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)]在老年冠心病患者诊断与预后评估中的临床意义。方法选取2019年2月至2022年2月聊城市第四人民医院接诊的80例老年冠心病患者作为A组,另选取同期80名健康体检者作为B组。A组根据冠状动脉病变支数分为单支病变组(n=23)、双支病变组(n=30)与多支病变组(n=27),根据预后情况分为预后良好组(n=60)与预后不良组(n=20)。比较A组与B组,单支病变组、双支病变组与多支病变组,预后良好组与预后不良组的血清sd LDL-C、IL-6及hs-CRP水平。结果A组血清sd LDL-C、IL-6及hs-CRP水平均高于B组,差异有统计学意义(P<0.05)。多支病变组血清sd LDL-C、hs-CRP、IL-6水平均高于单支病变组、双支病变组,双支病变组高于单支病变组,差异有统计学意义(P<0.05)。预后良好组血清sd LDL-C、IL-6及hs-CRP水平均低于预后不良组,差异有统计学意义(P<0.05)。结论血清sd LDL-C、IL-6、hs-CRP在冠心病诊断及病情评估中具有较高的参考价值,且监测各指标水平变化有利于评估患者预后。Objective To explore the clinical significance of serum small dense low-density lipoprotein cholesterol(sd LDL-C)and inflammatory cytokines(interleukin-6[IL-6],high-sensitivity C-reactive protein[hs-CRP])in the diagnosis and prognosis evaluation of elderly patients with coronary heart disease.Methods 80 elderly patients with coronary heart disease who were treated in Liaocheng Fourth People's Hospital from February 2019 to February 2022 were selected as the group A,and another 80 healthy individuals who underwent physical examinations during the same period were selected as the group B.The group A were divided into the single vessel disease group(n=23),double vessel disease group(n=30)and the multi vessel disease group(n=27)according to the number of coronary artery lesions,they were also divided into the good prognosis group(n=60)and the poor prognosis group(n=20)according to the prognosis.The serum levels of sd LDL-C,IL-6 and hs-CRP were compared between the group A and the group B,among the single vessel disease group,double vessel disease group and the multi vessel disease group,as well as between the good prognosis group and the poor prognosis group.Results The levels of serum sd LDL-C,IL-6 and hs-CRP in the group A were higher than those in the group B,and the differences were statistically significant(P<0.05).The serum levels of sd LDL-C,hs-CRP and IL-6 in the multi vessel lesion group were higher than those in the single vessel lesion group and the double vessel lesion group,the double vessel lesion group was higher than the single vessel lesion group,and the differences were statistically significant(P<0.05).The serum levels of sd LDL-C,IL-6,and hs-CRP in the good prognosis group were lower than those in the poor prognosis group,and the differences were statistically significant(P<0.05).Conclusion Serum levels of sd LDL-C,IL-6 and hs-CRP have high reference value in the diagnosis and assessment of coronary heart disease,and monitoring changes in these indicators is beneficial for evaluating patient progn

关 键 词：老年冠心病 血清小而密低密度脂蛋白 炎症细胞因子 诊断价值 预后评估 

分 类 号：R54[医药卫生—心血管疾病]