黄芪益肾汤联合厄贝沙坦治疗早期糖尿病肾病对照研究  

Comparative study of Huangqi Yishen Decoction Combined with Irbesartan in Treatment of Early Diabetic Nephropathy

作　　者：郝开花 齐秦 刘晓萍 HAO Kaihua;QI Qin;LIU Xiaoping(Department of Endocrinology,Liangzhou Hospital,Wuwei,Gansu 733000,China)

机构地区：[1]武威市凉州医院内分泌科,甘肃武威733000

出　　处：《基层中医药》2025年第2期59-65,共7页Basic Traditional Chinese Medicine

摘　　要：目的探究黄芪益肾汤联合厄贝沙坦治疗早期糖尿病肾病的临床效果。方法选取2022年12月—2023年12月我院收治的154例早期糖尿病肾病患者,随机数字表法分为对照组、观察组。对照组采取西药治疗,观察组采用黄芪益肾汤联合西药治疗。对比两组患者糖代谢指标、肾功能指标、血脂指标水平和不良反应发生率及临床疗效。结果治疗后,观察组胰岛素抵抗指数、空腹血糖、餐后2h血糖、糖化血红蛋白、肾功能、TG、TC水平低于对照组,胰岛β细胞功能指数、HDL-c水平高于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05)。结论选取黄芪益肾汤和西药联合治疗早期糖尿病肾病患者,取得的治疗效果较为理想,能够对患者肾功能和糖代谢指标水平起到改善作用,且具有较高的安全性。Objective To explore the clinical effect of Huangqi Yishen Decoction combined with Irbesartan in the treatment of early diabetic nephropathy.Methods 154 patients with early diabetic nephropathy admitted to Liangzhou Hospital from December 2022 to December 2023 were randomly divided into a control group and an observation group.The control group was treated with Western medicine,and the observation group was treated with Huangqi Yishen Decoction combined with Western medicine.The glucose metabolism indexes,renal function indexes,blood lipid levels,incidence of adverse reactions,and clinical efficacy were compared between the two groups of patients.Results After treatment,the insulin resistance index,fasting blood glucose,2 h post-prandial blood glucose,glycated hemoglobin,renal function,TG,and TC levels in the observation group were lower than those in the control group,while the pancreatic beta-cell function index and HDL-c levels were higher than those in the control group(P<0.05);the total effective rate of the observation group was higher than that of the control group(P<0.05).Conclusion The combination of Huangqi Yishen Decoction and Western medicine in the treatment of patients with early diabetic nephropathy has achieved a satisfactory therapeutic effect.It can improve the levels of renal function and glucose metabolism indexes of patients with high safety.

关 键 词：黄芪益肾汤 西药治疗 早期糖尿病肾病 肾功能指标 

分 类 号：R587.2[医药卫生—内分泌]