中性粒细胞CD64在自身免疫性疾病合并细菌感染诊断中的价值  

Application of neutrophil CD64 in the diagnosis of autoimmune diseases complicated with bacterial infections

作　　者：金盼 李俊宇 潘富根 JIN Pan;LI Junyu;PAN Fugen(Department of Laboratory,the Fourth Affiliated Hospital,Zhejiang University School of Medicine,Yiwu 322000,China)

机构地区：[1]浙江大学医学院附属第四医院检验科,义乌322000

出　　处：《浙江医学》2025年第6期625-628,633,I0005,共6页Zhejiang Medical Journal

基　　金：金华市科技计划项目(2022-4-315)。

摘　　要：目的探讨中性粒细胞CD64(nCD64)在自身免疫性疾病(AID)合并细菌感染诊断中的价值。方法回顾性选取2022年6月至2023年5月浙江大学医学院附属第四医院收治的103例AID患者为研究对象,包括合并细菌感染49例(AID合并细菌感染组)和未合并细菌感染54例(AID组);另选取同期本院体检的50名健康志愿者为健康对照组。比较3组对象炎症指标[包括白细胞计数(WBC)、C反应蛋白(CRP)、红细胞沉降率(ESR)、降钙素原(PCT)、nCD64等],采用多因素logistic回归分析AID合并细菌感染的影响因素,绘制ROC曲线分析炎症指标对AID合并细菌感染的诊断效能。结果AID合并细菌感染组、AID组患者WBC、CRP、ESR、PCT、nCD64均明显高于健康对照组(均P<0.05),AID合并细菌感染组上述指标均高于AID组(均P<0.05)。nCD64(OR=1.077)、WBC(OR=1.089)、CRP(OR=1.086)、ESR(OR=1.089)、PCT(OR=1.079)均是AID合并细菌感染的独立影响因素(均P<0.01)。nCD64诊断AID合并细菌感染的AUC、灵敏度、特异度为0.879、0.957、0.927,其AUC分别高于WBC、CRP、ESR、PCT的0.739、0.745、0.712、0.727。结论nCD64对AID合并细菌感染的早期诊断效能较高,可作为参考指标。Objective To analyze the diagnostic value of neutrophile granulocyte CD64(nCD64)in autoimmune disease(AID)complicated with bacterial infection.Methods A total of 103 AID patients who visited the Fourth Affiliated Hospital,Zhejiang University School of Medicine from June 2022 to May 2023,they were divided into the AID+bacterial infection group(49 cases)and the AID group(54 cases).Fifty healthy volunteers who underwent physical examination in the same hospital during the same period were selected as the healthy control group.The imflammatory indicators,including white blood cell count(WBC),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),and procalcitonin(PCT),nCD64 were compared among the three groups,and multivariate logistic regression analysis was conducted to analyze influencing factors for AID complicated with bacterial infection.ROC curve was drawn to evaluate the performance of inflammatory indicators in the early diagnosis of AID complicated with bacterial infection.Results The WBC,CRP,ESR,PCT,and nCD64 of patients in AID+bacterial infection group and AID group were significantly higher than those of the healthy control group,and the indicators showed higher values in the AID+bacterial infection group when compared with AID group(all P<0.05).nCD64(OR=1.077),WBC(OR=1.089),CRP(OR=1.086),ESR(OR=1.089),and PCT(OR=1.079)were independent influencing factors for AID combined with bacterial infection(all P<0.01).The AUC,sensitivity and specificity of nCD64 for diagnosing AID combined with bacterial infection were 0.879,0.957 and 0.927,respectively,the AUC of which was higher than that of WBC(0.739),CRP(0.745),ESR(0.712)and PCT(0.727).Conclusion nCD64 shows good performance in early diagnosis of AID combined with bacterial infection,which can be used as a reference indicator.

关 键 词：中性粒细胞CD64 自身免疫性疾病 细菌感染 早期诊断 诊断效能 

分 类 号：R44[医药卫生—诊断学]