黄连素治疗类风湿关节炎作用机制研究进展  

Research Progress on the Mechanism of Berberine in the Treatment of Rheumatoid Arthritis

作　　者：江培妍 袁军[2] 石楷 黄慧丽 庞宁馨 佟颖[4] JIANG Peiyan;YUAN Jun;SHI Kai;HUANG Huili;PANG Ningxin;TONG Ying(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China;Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China;Nanchang Hongdu Hospital of Traditional Chinese Medicine,Nanchang 330038,Jiangxi,China;The First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]武汉大学人民医院,湖北武汉430060 [3]南昌市洪都中医院,江西南昌330038 [4]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《辽宁中医药大学学报》2025年第4期59-65,共7页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(82074364,82474412);黑龙江省自然科学基金联合引导项目(LH2019H115);黑龙江省卫生健康委科研课题(20230606010518)。

摘　　要：类风湿关节炎作为一种临床常见的风湿免疫性疾病,发病机制错综复杂,现阶段临床尚无法实现彻底治愈。目前治疗药物主要有非甾体类抗炎药、糖皮质激素、免疫调节剂等,能控制病情但不良反应明显。黄连素是从毛莨科黄连属植物黄连的根皮中提取的异喹啉类生物碱,具有镇痛、抗炎、促进骨再生等作用,可有效改善类风湿关节炎的持续性炎症、关节结构的破坏和功能障碍。然而,黄连素对于类风湿关节炎的治疗机制尚未阐明。作者查阅大量国内外文献发现,黄连素在改善类风湿患者临床症状及治疗关节炎动物模型等方面均展现显著疗效。文章主要分类综述黄连素治疗类风湿关节炎的作用机制,旨在为类风湿关节炎的研究及临床治疗提供理论依据,为中医药临床治疗疾病及新药挖掘提供思路及参考。As a common rheumatic immune disease,rheumatoid arthritis,has an intricate pathogenesis and cannot be completely cured at this stage.Current therapeutic drugs mainly include non-steroidal antiinflammatory drugs(NSAIDs),glucocorticoids,and immunomodulators,which can control the disease but have significant side effects.Berberine is an isoquinoline alkaloid extracted from the root and bark of berberis vulgaris,a plant in the family of brassicaceae,with analgesic,anti-inflammatory and bone regeneration effects,which can effectively improve the persistent inflammation,destruction of joint structure and dysfunction of rheumatoid arthritis.However,the therapeutic mechanism of safranin for rheumatoid arthritis has not been elucidated.The authors reviewed a large number of domestic and international literature and found that safranin showed significant efficacy in improving clinical symptoms of rheumatoid patients and treating animal models of arthritis.This paper summarizes the mechanism of berberine in the treatment of rheumatoid arthritis and aims to provide a theoretical basis for the research and clinical treatment of rheumatoid arthritis,as well as ideas and references for the clinical treatment of traditional Chinese medicine and the excavation of new drugs development.

关 键 词：黄连素 类风湿关节炎 作用机制 研究进展 

分 类 号：R259[医药卫生—中西医结合]