丹皮酚治疗帕金森病药理作用机制研究进展  

Research Progress on Pharmacological Mechanism of Paeonol in the Treatment of Parkinson's Disease

作　　者：杜松 范佩娟 王夏[1] 侯唯一 刘燕妮[1,2] DU Song;FAN Peijuan;WANG Xia;HOU Weiyi;LIU Yanni(Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,Shaanxi,China;Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,Shaanxi,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学附属医院,陕西咸阳712000

出　　处：《辽宁中医药大学学报》2025年第4期109-113,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：中国民族医药学会科研项目(2020ZY125-410111);陕西中医药大学附属医院国家临床研究基地专项建设项目(2020LCJD001);陕西中医药大学校级项目(2023GP37)。

摘　　要：帕金森病是最常见的神经退行性疾病之一,其以中脑黑质致密区多巴胺神经元丢失和出现路易小体为主要病理特征,对人们的日常生活造成极大影响。目前对于帕金森病尚无根治方法,但用中药治疗帕金森病一直是研究热点。传统中药牡丹皮作为治疗帕金森病的常用中药,具有清热凉血、活血化瘀、清肝泻火之功效,从天然植物中发现有效药物成分并研究其作用机制是有别于化学合成药物的研究思路。丹皮酚又称牡丹酚,是传统中药牡丹皮的主要有效成分。丹皮酚是一种有效的抗炎和抗氧化剂,丹皮酚的药理作用十分广泛,查阅相关文献,发现丹皮酚可通过多靶点、多途径治疗帕金森病,能有效延缓病情的进展。丹皮酚发挥其抗炎、抗抑郁和抗氧化和镇痛等作用,对治疗帕金森病疗效显著。该文总结了丹皮酚治疗帕金森病的药理作用机制,以期为丹皮酚治疗帕金森病的未来研究方向提供参考。Parkinson's disease is one of the most common neurodegenerative diseases,which is characterized by the loss of dopamine neurons and Lewy body in the substantia nigra,and has a great impact on people's daily life.At present,there is no radical cure for Parkinson's disease,but the treatment of TCM has been a research focus.As a traditional Chinese medicine for the treatment of Parkinson's disease,the traditional Chinese medicine Mudanpi(Moutan Cortex)has the effect of clearing heat and cooling blood,I,et al.Worldwide prevalence,risk factors and psychological impact of infertility among women:a systematic review and metaanalysis promoting blood circulation and removing blood stasis,and clearing liver and reducing fire.It is different from the effective drug ingredients from natural plants and the study of its action mechanism.Paeonol,also known as peony phenol,is the main active ingredient of traditional Chinese medicine Mudanpi(Moutan Cortex).Paeonol is an effective anti-inflammatory and antioxidant,the pharmacological effect of papicol is very extensive,review the relevant literature,found that papicol can treat Parkinson's disease through multiple targets and multiple ways,can effectively delay the progression of the disease.Paeonol exerts its anti-inflammatory,anti-antidepressant and anti-oxidation and analgesic effects,and has remarkable efficacy in the treatment of Parkinson's disease.This paper summarizes the pharmacological mechanism of Parkinson's disease treatment in order to provide reference for future research directions in Parkinson's disease treatment.

关 键 词：帕金森病 丹皮酚 药理作用 研究进展 

分 类 号：R285[医药卫生—中药学]