黄芪复方、药对及活性成分治疗结直肠癌作用机制研究进展  

Advances of the Mechanism of Huangqi(Astragalus Radix)Compound,Drug Pairs,and Active Ingredients in the Treatment of Colorectal Cancer

作　　者：卢瑶瑶 白克运[2] 谷超[2] 刘晨馨 LU Yaoyao;BAI Keyun;GU Chao;LIU Chenxin(Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学附属医院,山东济南250014

出　　处：《辽宁中医药大学学报》2025年第4期127-133,共7页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：山东省中医药重点学科项目(YYPP2023-21);山东省中医药科技发展计划项目(2019-0138);齐鲁中医药优势专科集群项目(YWC2022ZKJQ0003)。

摘　　要：结直肠癌是我国常见的消化道恶性肿瘤,发病率和病死率呈现持续增长的趋势,严重威胁人类身体健康。目前结直肠癌常规治疗以手术、放化疗、靶向治疗等手段为主,但存在一定局限性。因此,探索新型治疗药物抑制结肠癌的进展显得尤为重要。中药在肿瘤的治疗中具有多靶点、效果显著、不良反应小等西医不可替代的优势,作用效应日益凸显。中药黄芪及其活性成分具有良好的抗结直肠癌作用,干预机制表现为抑制肿瘤细胞增殖、侵袭及转移、诱导凋亡、增强机体免疫功能、改善肿瘤微环境、联合化疗药物减毒增效等。通过梳理近5年文献,对黄芪复方、药对及其活性成分治疗结直肠癌的作用机制的临床和实验研究进行综述,为黄芪的临床运用提供更加合理有效的依据,并为抗结直肠癌新型药物的研发提供参考。Colorectal cancer is a common malignant tumor of the digestive system in China,with increasing incidence and mortality rates,posing a serious threat to human health.Current conventional treatments for colorectal cancer mainly include surgery,radiotherapy,chemotherapy,and targeted therapy,but they have certain limitations.Therefore,exploring new effective drugs to inhibit the progression of colon cancer is particularly important.Traditional Chinese medicine has irreplaceable advantages in cancer treatment,such as multiple targets,significant effects,and minimal adverse reactions,with increasing emphasis on its therapeutic effects.Huangqi(Astragalus Radix),a Chinese herbal medicine,and its active ingredients have shown good anti-colorectal cancer effects.The intervention mechanism includes inhibiting tumor cell proliferation,suppressing tumor cell invasion and metastasis,inducing tumor cell apoptosis,enhancing immune function,improving the tumor microenvironment,and reducing toxicity and enhancing efficacy when combined with chemotherapy drugs.This review summarizes clinical and experimental studies on the mechanisms of action of Huangqi(Astragalus Radix)compound,drug pairs,and their active ingredients in treating colorectal cancer over the past five years,providing a more rational and effective basis for the clinical application of Huangqi(Astragalus Radix)and serving as a reference for the development of new drugs for colorectal cancer treatment.

关 键 词：黄芪复方 黄芪药对 黄芪活性成分 结直肠癌 作用机制 

分 类 号：R285[医药卫生—中药学]