火炭母化学成分及药理作用研究进展  

Research Progress on Chemical Constituents and Pharmacological Effects of Huotanmu(Herba Polygoni Chinensislor)

作　　者：谢凤凤 朱华[1,2,3] XIE Fengfeng;ZHU Hua(Guangxi University of Chinese Medicine,Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,the Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine,Guangxi Engineering Research Center of Ethnic Medicine Resources and Application,Nanning 530200,Guangxi,China;Guangxi Minzu University,Nanning 530006,Guangxi,China;Guangxi Institute for DRUG Control,NMPA Key Laboratory of Quality Monitoring and Evaluation of Traditional Chinese Medicine,Chinese Materia Medica,Nanning 530018,Guangxi,China)

机构地区：[1]广西中医药大学,广西壮瑶药重点实验室,壮瑶药协同创新中心,广西壮族自治区民族药资源与应用工程研究中心,广西南宁530200 [2]广西民族大学,广西南宁530006 [3]广西壮族自治区药品检验研究院,国家药品监督管理局中药材质量监测与评价重点实验室,广西南宁530018

出　　处：《辽宁中医药大学学报》2025年第4期182-192,共11页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广西重点研发计划资助项目(桂科AB21196016);广西科技基地和人才专项资助项目(桂科AD21238031);广西高校中青年教师科研基础能力提升资助项目(2022KY0286);广西壮族自治区药品监督管理局药品科研计划资助项目(桂药监科直属〔2023〕034号);广西中医药重点学科壮药学资助项目(GZXK-Z-20-64)。

摘　　要：火炭母在广西和广东地区用药历史悠久,药材资源丰富,作为壮、瑶等民族用药。文章结合国内外发表的相关文献,对壮瑶药火炭母化学成分及现代药理作用进行文献综述,结果发现火炭母中报道的化学成分复杂多样,通过高效液相色谱法、紫外分光光度法、红外分光光度法、电喷雾质谱、核磁共振氢谱、碳谱等多种鉴定手段,识别了火炭母中206种化合物,包括芹菜素、槲皮素等黄酮类43种、鞣花酸、没食子酸等酚酸类53种、3-乙烯基环辛烯、松油烯等挥发油类87种及其他类23种。现代药理作用有抗炎、抗菌、抗氧化、镇痛、抗病毒、解热、抗肿瘤、抗腹泻等功效。此外,研究发现具有药效活性的主要是火炭母提取物,关于火炭母中单体化合物活性研究较少,药效物质基础和作用机制不够明确。可见,对药材中药效物质及其发挥的药理作用和作用机制进行深入系统的研究,为火炭母资源开发及临床用药提供更清晰的证据。Huotanmu(Herba Polygoni Chinensislor)has a long history of medication in Guangxi and Guangdong,with rich medicinal resources,and is used as a ethnic drug in Zhuang and Yao.Based on the relevant literature published at home and abroad,this paper reviews the chemical constituents and modern pharmacological effects of Huotanmu(Herba Polygoni Chinensislor).The results show that the chemical constituents reported in Huotanmu(Herba Polygoni Chinensislor)are complex and diverse.Through high performance liquid chromatography,ultraviolet spectrophotometry,infrared spectrophotometry,electrospray mass spectrometry,nuclear magnetic resonance hydrogen spectrum,carbon spectrum and other identification methods,206 compounds in Huotanmu(Herba Polygoni Chinensislor)were identified,including 43 flavonoids such as apigenin and quercetin,53 phenolic acids such as ellagic acid and gallic acid,87 volatile oils such as 3-vinylcyclooctene and terpinene,and 23 other kinds.Modern pharmacological effects have anti-inflammatory,antibacterial,antioxidant,analgesic,antiviral,antipyretic,anti-tumor,anti-diarrhea and other effects.In addition,the study found that the main medicinal activity is the extract of Huotanmu(Herba Polygoni Chinensislor).There are few studies on the activity of monomer compounds in Huotanmu(Herba Polygoni Chinensislor),and the pharmacodynamic material basis and mechanism of action are not clear enough.It can be seen that the indepth and systematic study of the effective substances in the medicinal materials and their pharmacological effects and mechanism of action will provide clearer evidence for the development of the resources and clinical medication of the Huotanmu(Herba Polygoni Chinensislor).

关 键 词：壮瑶药 火炭母 化学成分 药理作用 

分 类 号：R284[医药卫生—中药学]