线粒体自噬在绝经后骨质疏松症中的调控机制  

Regulatory Mechanism of Mitochondrial Autophagy in Postmenopausal Osteoporosis

作　　者：陈明杏 文皓楠 刘小钰[1] 梁海峰 张荣伟 宋敏[1,2] CHEN Mingxing;WEN Haonan;LIU Xiaoyu;LIANG Haifeng;ZHANG Rongwei;SONG Min(Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,Gansu,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730020

出　　处：《辽宁中医药大学学报》2025年第4期209-214,共6页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81960877,81960878);甘肃省高等学校产业支撑计划项目(2022CYZC-52);甘肃省中医药研究中心开放课题(zyzx-2023-14)。

摘　　要：线粒体是维持细胞代谢和生物内稳态的基础细胞器,在心血管、内分泌、癌症等诸多疾病的发生发展过程中起着不可或缺的作用。线粒体自噬作为生物体内一种重要的细胞清除方式,能够有效地清除损伤或失效的线粒体,可以影响骨细胞的成熟和功能表达,进而影响骨代谢和骨稳态,与骨科疾病的发生、发展关系密切。绝经后骨质疏松症是以骨密度降低、骨微结构变化和骨折风险增加为特点的骨代谢疾病,严重影响患者生活质量,现已成为全球重大健康问题。绝经后雌激素水平下降可导致线粒体功能障碍和自噬紊乱,进而影响骨细胞的代谢和功能,因此调控线粒体自噬过程可能成为治疗绝经后骨质疏松症的新视角。文章旨在探讨线粒体自噬在PMOP进展中的干预作用和机制研究,主要从其作用机制、干预途径、影响因素、调控方式等层面进行阐述,以期了解其在绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)发生发展中的作用机理,进一步拓展PMOP的防治策略。Mitochondria are the basic organelles that maintain cell metabolism and biological homeostasis,and play an indispensable role in the occurrence and development of cardiovascular,endocrine,cancer and many other diseases.Mitochondrial autophagy,as an important cell clearance mode in vivo,can effectively remove damaged or ineffective mitochondria,affect the maturation and functional expression of bone cells,and then affect bone metabolism and bone homeostasis,which is closely related to the occurrence and development of orthopedic diseases.Postmenopausal osteoporosis(PMOP)is a bone metabolic disease characterized by decreased bone density,changes in bone microstructure and increased risk of fracture,which seriously affects patients'quality of life and has become a major global health problem.The decrease of estrogen level after menopause can lead to mitochondrial dysfunction and autophagy disorder,and then affect the metabolism and function of bone cells.Therefore,regulating the process of mitochondrial autophagy may become a new perspective for the treatment of postmenopausal osteoporosis.This paper aims to explore the intervention role and mechanism of mitochondrial autophagy in the progression of PMOP,mainly from the aspects of its mechanism of action,intervention pathway,influencing factors,regulation mode,etc.,in order to understand its mechanism of action in the occurrence and development of PMOP and further expand the prevention and treatment strategies of PMOP.

关 键 词：线粒体自噬 绝经后骨质疏松症 骨代谢 调控机制 中医药防治策略 

分 类 号：R259[医药卫生—中西医结合]