儿童自身免疫性肝病及其实验室诊断进展  

Autoimmune liver disease in children and progress of laboratory diagnosis

作　　者：马展 翁文浩 MA Zhan;WENG Wenhao(Department of Clinical Laboratory,Shanghai Children's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200062,China)

机构地区：[1]上海市儿童医院上海交通大学医学院附属儿童医院检验科,上海200062

出　　处：《检验医学》2025年第3期218-222,共5页Laboratory Medicine

基　　金：国家自然科学基金项目(82372327)。

摘　　要：自身免疫性肝病(ALD)是因人体免疫功能紊乱引起的一大类慢性进展性肝组织炎症。近年来,儿童ALD的发病率呈升高趋势。儿童ALD的发病情况、临床特点、实验室诊断等与成人均有一定的差异。文章对常见儿童ALD的分类和特征、实验室诊断现状和进展、尚待解决的问题和遗传易感性进行综述,以期为儿童ALD的临床研究和疾病诊治提供参考。Autoimmune liver diseases(ALD)is a group of chronic progressive inflammation of liver caused by immune dysfunction.In the recent years,the incidence of ALD in children has risen significantly.The occurrence,clinical characteristics and laboratory diagnosis of ALD in children differ notably from those in adults.This review focuses on the classification and characteristics of common ALD in children,the status and development in laboratory diagnosis,unresolved challenges and genetic susceptibility.The aim is to provide a reference for clinical research and to improve the diagnosis and treatment of ALD in children.

关 键 词：自身免疫性肝病 儿童 实验室诊断 

分 类 号：R446.62[医药卫生—诊断学]