Generating Synthetic Data for Machine Learning Models from thePediatric Heart Network Fontan I Dataset  

作　　者：Vatche Bahudian John Valdovinos 

机构地区：[1]Department of Electrical and Computer Engineering,California State University Northridge,Northridge,CA 91330,USA

出　　处：《Congenital Heart Disease》2025年第1期115-127,共13页先天性心脏病(英文)

摘　　要：Background: The population of Fontan patients, patients born with a single functioningventricle, is growing. There is a growing need to develop algorithms for this population that can predicthealth outcomes. Artiffcial intelligence models predicting short-term and long-term health outcomes forpatients with the Fontan circulation are needed. Generative adversarial networks (GANs) provide a solutionfor generating realistic and useful synthetic data that can be used to train such models. Methods: Despitetheir promise, GANs have not been widely adopted in the congenital heart disease research communitydue, in some part, to a lack of knowledge on how to employ them. In this research study, a GAN was usedto generate synthetic data from the Pediatric Heart Network Fontan I dataset. A subset of data consistingof the echocardiographic and BNP measures collected from Fontan patients was used to train the GAN.Two sets of synthetic data were created to understand the effect of data missingness on synthetic datageneration. Synthetic data was created from real data in which the missing values were imputed usingMultiple Imputation by Chained Equations (MICE) (referred to as synthetic from imputed real samples). Inaddition, synthetic data was created from real data in which the missing values were dropped (referred to assynthetic from dropped real samples). Both synthetic datasets were evaluated for ffdelity by using visualmethods which involved comparing histograms and principal component analysis (PCA) plots. Fidelitywas measured quantitatively by (1) comparing synthetic and real data using the Kolmogorov-Smirnovtest to evaluate the similarity between two distributions and (2) training a neural network to distinguishbetween real and synthetic samples. Both synthetic datasets were evaluated for utility by training aneural network with synthetic data and testing the neural network on its ability to classify patients thathave ventricular dysfunction using echocardiograph measures and serological measures. Results: Usinghistograms

关 键 词：Synthetic data congenital heart disease Fontan circulation 

分 类 号：R65[医药卫生—外科学]