2020~2024年生殖医学科患者支原体感染情况及药敏分析  

An Analysis of Mycoplasma Infections and Antimicrobial Susceptibility Among Patients in the Reproductive MedicineDepartment from 2020 to 2024

作　　者：梁洁玲[1] 王发雄 龚彩平 马建宏 赵越 LIANG Jieling;WANG Faxiong;GONG Caiping;MA Jianhong;ZHAO Yue(Department of Clinical Laboratory,Guangdong Provincial People’s Hospital/Guangdong Academy of Medical Sciences,Southern Medical University,Guangzhou 510080,China)

机构地区：[1]南方医科大学附属广东省人民医院/广东省医学科学院检验科,广东广州510080

出　　处：《标记免疫分析与临床》2025年第2期280-283,289,共5页Labeled Immunoassays and Clinical Medicine

基　　金：广东省医学科学技术研究基金项目(编号:B2023026)。

摘　　要：目的探讨医院生殖医学科患者泌尿生殖道支原体感染的状况及其药敏特征,为临床诊疗及抗菌药物的优化提供科学依据。方法回顾性分析2020年1月至2024年12月广东省人民医院生殖医学科就诊的3643例患者资料,其中男性2293例,女性1350例。对其泌尿生殖道分泌物样本进行支原体培养及药敏试验,检测解脲脲原体(Uu)和人型支原体(Mh)的感染情况及对10种抗菌药物的敏感性,并应用SPSS 22.0软件进行统计学分析。结果在3643例患者中,共检测出支原体阳性725例,总感染率为19.90%。其中,Uu单一感染663例(91.45%),Uu+Mh混合感染53例(7.31%),Mh单一感染9例(1.24%)。女性感染率显著高于男性(P<0.001),30~39岁患者的感染比例最高,占54.07%。药敏试验结果显示,Uu对大环内酯类和四环素类药物具有较高敏感性,敏感率超过95.0%,而对氧氟沙星和环丙沙星的敏感率较低。Uu+Mh混合感染组对10种抗菌药物的非敏感性均显著高于Uu单一感染组(P<0.05)。结论支原体感染在性别和年龄分布上存在差异,女性和30~39岁患者为主要感染人群。Uu对大环内酯类和四环素类药物保持高敏感性,而Mh表现出更强的耐药性。临床需结合病原学检测结果,合理选用抗菌药物,同时加强药物使用管理,以遏制耐药菌株的产生与扩散。Objective To investigate the prevalence of urogenital Mycoplasma infections and antimicrobial susceptibility patterns among patients in a Reproductive Medicine Department,so as to provide data-driven evidences to inform clinical diagnosis,treatment,and the optimization of antimicrobial strategies.Methods A retrospective study was conducted on 3643 patients who were admitted in the Reproductive Medicine Department at Guangdong Provincial People’s Hospital between January,2020 and December,2024.This patient cohort included 2293 males and 1350 females.Urogenital secretion samples were collected for Mycoplasma culture and antimicrobial susceptibility testing,with a focus on Ureaplasma urealyticum(Uu)and Mycoplasma hominis(Mh)infections.Sensitivities to 10 antimicrobial agents were assessed,and statistical analysis was performed using SPSS 22.0 software.Results Among 3643 patients in our study,725 showed positive for Mycoplasma,yielding an overall infection rate of 19.90%.Uu mono-infections accounted for 663 cases(91.45%),while Uu+Mh co-infections for 53 cases(7.31%),and Mh mono-infections for 9 cases(1.24%).Females exhibited a significantly higher infection rate than males(P<0.001).Patients aged 30-39 years represented the highest proportion of infections(54.07%).Drug susceptibility testing showed that Uu was highly sensitive to macrolides and tetracyclines,with sensitivity rates exceeding 95.0%,while displayed a relatively lower sensitivity to ofloxacin and ciprofloxacin.The Uu+Mh co-infection group exhibited significantly greater resistance to all 10 tested antibiotics compared to the Uu mono-infection group(P<0.05).Conclusion Mycoplasma infections exhibit distinct variations by gender and age groups,with females and patients aged 30-39 years constituting the primary affected populations.Uu maintains high sensitivity to macrolides and tetracyclines,whereas Mh demonstrates greater resistance.Effective clinical management should fully leverage pathogen detection results to better guide targeted antibiotic selection

关 键 词：泌尿生殖道 生殖医学科 解脲脲原体 人型支原体 药敏试验 

分 类 号：R711.3[医药卫生—妇产科学] R518.7[医药卫生—临床医学]