不同炎症指标与输尿管结石伴肾积水的相关性研究  

The Correlation Between Different Inflammatory Indicators and Ureteral Stones with Hydronephrosis

作　　者：陈珊珊 唐钧 CHEN Shanshan;TANG Jun(Clinical laboratory of Ting Lin Hospital in Shanghai Jin Shan District,Shanghai 201505,China)

机构地区：[1]上海市金山区亭林医院检验科,上海201505

出　　处：《标记免疫分析与临床》2025年第2期284-289,共6页Labeled Immunoassays and Clinical Medicine

基　　金：国家重点研发计划“国家质量基础的共性技术研究与应用”重点专项子课题项目(编号:2019YFF0216502)。

摘　　要：目的探究不同炎症指标与输尿管结石伴肾积水之间的相关性,以评估炎症反应对输尿管结石伴肾积水患者肾功能损害的影响。方法回顾性选取2022年1月至2023年6月我院收住的输尿管结石患者117例,根据是否合并肾积水将其分为肾积水组(57例)和无肾积水组(60例),选取同期健康体检者242例作为健康对照组。比较不同组间NLR、PLR、RDW等炎症指标水平,运用Pearson相关性分析研究不同炎症指标与患者肾功能指标的相关性,绘制ROC曲线量化各个指标的诊断效能并计算最佳截断值。结果肾积水组患者NLR、PLR、RDW等炎症指标水平均高于对照组和无肾积水组(均P<0.05)。NLR水平与输尿管结石伴肾积水患者的Scr、BUN、UA呈现显著的正相关关系(r分别为0.934、0.976、0.867);PLR水平与输尿管结石伴肾积水患者的Scr、BUN、UA呈现显著的正相关关系(r分别为0.151、0.264、0.611);RDW水平与输尿管结石伴肾积水患者的Scr、BUN、UA呈现显著的正相关关系(r分别为0.991、0.983、0.706)。NLR、PLR、RDW预测输尿管结石伴肾积水的效能分别为AUC=0.784(95%CI:0.693~0.875),AUC=0.678(95%CI:0.578~0.778),AUC=0.814(95%CI:0.644~0.824)。结论炎症指标与输尿管结石伴肾积水之间存在一定相关性,干预炎症反应可能有助于改善输尿管结石伴肾积水患者预后。Objective To explore and identify the correlation between different inflammatory indicators and ureteral stones with hydronephrosis,in order to evaluate the impact of inflammatory response on renal function damage in patients with ureteral stones.Methods A retrospective selection was conducted on 117 patients with ureteral stones admitted to our hospital from January,2022 to June,2023.These patients were divided into a hydronephrosis group(57 cases)and a non-hydronephrosis group(60 cases)based on the presence of hydronephrosis.In addition,242 healthy individuals who underwent physical examinations during the same period were selected as the healthy control group.We compared the levels of inflammatory markers,such as NLR,PLR,and RDW,between different groups,and applied Pearson correlation analysis to identify the correlation between different inflammatory markers and renal function indicators.Results The levels of inflammatory markers,such as NLR,PLR,and RDW,in the patients with hydronephrosis were significantly higher than those in the control group and the group without hydronephrosis(all P<0.05).There was a significant positive correlation between NLR levels and Scr,BUN,and UA in patients with ureteral stones and hydronephrosis(r=0.934,0.976,0.867,respectively);There was a significant positive correlation between PLR levels and Scr,BUN,and UA in patients with ureteral stones and hydronephrosis(r=0.151,0.264,0.611,respectively);The RDW level was significantly positively correlated with Scr,BUN,and UA in patients with ureteral stones and hydronephrosis(r=0.991,0.983,0.706,respectively).The efficacy of NLR,PLR,and RDW in predicting ureteral stones with hydronephrosis was evaluated by ROC curves with results as follows:AUC=0.784(95%CI:0.693 to 0.875),AUC=0.678(95%CI:0.578 to 0.778),and AUC=0.814(95%CI:0.644 to 0.824),respectively.Conclusion There is a correlation between inflammatory indicators and ureteral stones with hydronephrosis,and intervening in inflammatory response could help improve the prognosis of patie

关 键 词：炎症指标 输尿管结石 肾积水 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 

分 类 号：R445.1[医药卫生—影像医学与核医学]