青岛地区女性人乳头瘤病毒感染特点分析  

Characteristics of Female Human Papillomavirus Infectionsin Qingdao Area

作　　者：王仁峰 胥兴丽 王亚秋[1] 宋金莲[1] WANG Renfeng;XU Xingli;WANG Yaqiu;SONG Jinlian(Department of Laboratory,Women and Children’s Hospital Affiliated to Qingdao University,Qingdao 266000,China;Department of Laboratory,Qingdao Municipal Hospital,Qingdao 266000,China)

机构地区：[1]青岛大学附属妇女儿童医院检验科,山东青岛266000 [2]青岛市市立医院检验科,山东青岛266000

出　　处：《标记免疫分析与临床》2025年第2期326-330,340,共6页Labeled Immunoassays and Clinical Medicine

基　　金：青岛市医疗卫生重点学科建设项目资助。

摘　　要：目的了解青岛地区女性人乳头瘤病毒(HPV)感染现状及特点,为HPV感染防控提供参考依据。方法将16418例于我院就诊并初次进行HPV筛查的成年女性纳入本研究,分析HPV感染情况、免疫球蛋白水平、阴道微生态情况及不同ABO血型人群HPV感染差异。结果2018年至2022年HPV阳性共计4104例(25.0%),高危型HPV(hrHPV)感染患者3292例(20.1%),不同年份HPV/hrHPV感染率差异有统计学意义(P<0.001);不同基因型HPV感染率从高到低前6位为HPV16、52、58、61、53、56,患者以高危型HPV单独感染(2316例)及高危型HPV相关混合感染(976例)为主;不同年龄组HPV/hrHPV感染率差异有显著统计学意义(χ^(2)=162.9/131.1,P<0.001),18~25岁女性人群HPV/hrHPV感染率最高(38.10%/30.50%),31~35岁女性人群感染率最低(21.85%/17.28%);HPV阳性组与阴性组IgA、IgG、IgM表达水平差异无统计学意义(P>0.05);与HPV阴性组相比,HPV阳性组阴道分泌物pH值显著升高(P<0.001);A型血人群HPV/hrHPV感染率较B型血人群升高,差异有统计学意义(P=0.043/0.037)。结论青岛地区HPV感染率相对较高,以高危型及高危混合型感染为主,其感染与年龄、阴道微生态及ABO血型相关。Objective To investigate the general status and characteristics of female papillomavirus(HPV)infections in Qingdao area,and to provide future reference for the prevention of HPV infections.Methods A total of 16418 adult women who received initial HPV screening in our hospital were included in this study.HPV infections across different years and groups were analyzed.The expression of immunoglobulin protein,vaginal microecology and the distribution of ABO blood groups between HPV positive group and negative group were also analyzed.Results From 2018 to 2022,a total of 4104 patients(25.0%)were infected with HPV,and of whom 3292 patients(20.1%)were infected with high-risk HPV(hrHPV),showing statistically significant differences in HPV/hrHPV infection rates among different years(P<0.001).The top six HPV types with infection rates from high to low were:HPV16,52,58,61,53 and 56.Patients were mainly infected with hrHPV alone(2316 cases)or hrHPV mixed with other types(976 cases).There were statistically significant differences in HPV/hrHPV infection rates among different age groups(χ^(2)=162.9/131.1,P<0.001).The highest HPV/hrHPV infection rate was found in females,aged 18-25(38.10%/30.50%),while the lowest was found in females,aged 31-35(21.85%/17.28%).There were no significant differences in the expression levels of IgA,IgG and IgM between HPV positive and negative groups(P>0.05).Compared with the HPV-negative group,the PH value of vaginal secretions in the HPV-positive group was significantly increased(P<0.001).The infection rate of HPV/hrHPV in blood group A was significantly higher than that in blood group B(P=0.043/0.037).Conclusion HPV infection rate is relatively high in Qingdao area,which could be mainly caused by hrHPV.The infection status is related to age,vaginal microecology and ABO blood group.

关 键 词：人乳头瘤病毒 基因分型 感染率 酸碱度 血型 

分 类 号：R373.9[医药卫生—病原生物学]